用HPLC法测定血清药物浓度。
证实采用常规给药方法血清药物浓度较高且持续时间短,包埋缓释药物血清浓度较低、持续时间较长。
The serum drug is higher and shorter time by the routine methods. The serum concentration of FT-207 is lower and retarded by implanted.
减量重复给药后发现,随着第二次给药剂量减少,脑组织中药物浓度与血清药物浓度的比值下降至0.7,近似可接近单次给药后的比值。
In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.
一种药物,通过其使肠内胆汁酸泌结以及促进它们分泌的能力,用以降低血清内胆固醇浓度以及治疗与黄疸病相关的疥疮。
A drug used to lower serum cholesterol levels and treat itching associated with jaundice through its ability to bind intestinal bile acids and promote their excretion.
结论:在癫痫的病程和丙戊酸钠治疗中,血清fsh的浓度升高,其机制可能与疾病和药物的共同作用有关。
Conclusion: During the disease course and VPA therapy of epilepsy, the serum concentration of FSH is ascending. The mechanism might be the interaction of both the disease and the drug.
目的建立测定药物依赖症患者血清中氯硝安定(CZP)浓度的RP—HPLC法,为临床用药提供依据。
OBJECTIVE To develop a RP-HPLC method for the determination of clonazepam (CZP) in serum of drug-dependent patients to provide a scientific basis for clinical use of CZP.
药物组OD值明显高于对照组(P<0.05),而且有一定的血清浓度依赖性。
MTT colorimetric assay revealed experimental groups elevated OD value compared with control groups(P< 0.05).
目的:采用高效液相-荧光色谱法测定人血清中拉呋替丁药物浓度,研究临床推荐剂量下的健康人体药动学。
OBJECTIVE To determine prazosin hydrochloride in human plasma by HPLC-MS method, and to investigate its pharmacokinetics and bioequivalance.
目的:采用高效液相-荧光色谱法测定人血清中拉呋替丁药物浓度,研究临床推荐剂量下的健康人体药动学。
OBJECTIVE To determine prazosin hydrochloride in human plasma by HPLC-MS method, and to investigate its pharmacokinetics and bioequivalance.
应用推荐