蛋白偶联受体gpr40是脂肪酸的特异性受体。
The G protein-coupled receptor, GPR40, is a specific receptor for free fatty acids.
当触发这一反应后，G -蛋白偶联受体又从细胞膜上回到细胞浆。
After the response is triggered, the receptor retreats from the membrane into the cell's interior.
蛋白偶联受体在心脏病、血压调节、炎症和心理疾病中扮演关键角色。
G protein-coupled receptors play a critical role in heart disease, blood pressure regulation, inflammation and psychological disorders.
蛋白偶联受体属于跨膜蛋白的大家族，在药物设计中起着很重要的作用。
G-protein Coupled Receptors (GPCRs) belong to one of the largest superfamilies of membrane proteins and are important targets for drug design.
蛋白偶联受体具有重要的生理功能和病理意义，已成为一类重要的药物靶点。
Protein-coupled receptors are a group of drug targets with important physiological functions and of pathological significance.
MrgX2是一个在外周神经系统的感觉神经元特异表达的G蛋白偶联受体。
MRGX2, a G-protein-coupled receptor, is specifically expressed in the sensory neurons of the human peripheral nervous system and involved in nociception.
蛋白偶联受体家族成员超过300种，它们构成了细胞膜中最大的蛋白质家族。
With more than 300 members, the G protein-coupled receptors constitute the largest family of proteins found in the membranes of cells.
G蛋白偶联受体具有重要的生理功能和病理意义，已成为一类重要的药物靶点。
G Protein-coupled receptors are a group of drug targets with important physiological functions and of pathological significance.
酪氨酸激酶型受体、G蛋白偶联受体和离子通道型受体是细胞表面三类主要受体。
Receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCR) and ion channel receptors are main cell surface receptors.
昆虫的气味受体长久以来被认为是一种G蛋白偶联受体，遵循从线虫到人类的通用模式。
The insect odorant receptors, as other odorant receptors from nematoid to human, have long been perceived to be G-protein-coupled receptors(GPCR).
本发明公开了通过应用辅助基因的共表达来实现或改进G蛋白偶联受体的功能分析的方法。
Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes.
G -蛋白偶联受体分布于细胞膜，与行使细胞通讯的分子(如神经递质和激素)发生相互作用。
Found in the cell membrane, GPCRs interact with molecules responsible for cellular communication such as neurotransmitters and hormones.
溶血磷脂酸(LPA)是一种生物活性磷脂介质，主要通过G蛋白偶联受体发挥多种生物学功能。
Lysophosphatidic acid (LPA) is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly, through G-protein coupled receptors.
这类G蛋白偶联受体中的绝大部分对激素和神经递质有反应，它们在自然中并不丰富且在结构上趋于不稳定。
The vast majority of these G protein-coupled receptors respond to hormones and neurotransmitters. They are not naturally abundant and tend to be structurally unstable.
CCR5为细胞膜蛋白，属于G蛋白偶联受体家族的成员，是HIV - 1入侵机体细胞的主要辅助受体之一。
CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1infection.
本发明还公开了检测G蛋白偶联受体核酸序列中的突变的诊断方法以及检测受体的可溶形式的改变水平的诊断方法。
Also, disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
当研究人员引入与其相应的膜不通透性荧光团并与细胞膜上有荧光团激活蛋白质标签的G-蛋白偶联受体结合时，发出明亮的荧光；
When the researchers introduced its associated membrane-impermeant fluorogen, it bound to the FAP-tagged GPCR on the cell surface, emitting a bright fluorescent glow.
STAT蛋白可被G 蛋白偶联受体激活，而CCK 受体作为一种G 蛋白偶联受体，是否对JAK／STAT通路具有直接激活作用，尚未见报道。
STAT proteins are activated by G-protein coupled receptors, while it has not been reported whether CCK receptors, a kind of G-protein coupled receptors, can activate JAK/STAT pathway.
摘要目的研究能通过叶酸受体介导靶向肿瘤细胞的叶酸偶联白蛋白纳米粒。
Objective: to study folate -conjugated albumin nanoparticles targeting to tumor cells via folate receptor-mediated endocytosis.
而细胞内膜受体G蛋白偶联的环磷腺苷浓度促进了细胞的各种功能，也参与调节了其他信号通路。
The concentration of adenosine cyclophosphate of membrane receptor G protein couple stimulates the functions of cells, and participates in regulating various signal transductions.
目的研究能通过叶酸受体介导靶向肿瘤细胞的叶酸偶联白蛋白纳米粒。
Objective: to study folate-conjugated albumin nanoparticles targeting to tumor cells via folate receptor-mediated endocytosis.
结论叶酸偶联的5氟尿嘧啶白蛋白能经叶酸受体介导靶向于叶酸受体丰富的肿瘤细胞。
Conclusion Folateconjugated 5fluorouracilalbumin could be targeted into tumor cells with rich folate receptors via folate receptormediated endocytosis significantly.
结论叶酸偶联的5氟尿嘧啶白蛋白能经叶酸受体介导靶向于叶酸受体丰富的肿瘤细胞。
Conclusion Folateconjugated 5fluorouracilalbumin could be targeted into tumor cells with rich folate receptors via folate receptormediated endocytosis significantly.
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