其功能与周期蛋白和周期蛋白依赖性激酶形成的异源三聚体存在化学计量关系。
It functions in stoichiometric relationships forming heterotrimeric complexes with cycling and cyclin-dependent kinases.
对有肺癌的实验鼠进行实验,研究发现依赖性蛋白激酶1 (Cdk1)让DNA停止修复。
In experiments on mice with lung tumours the researchers showed that blocking a molecule called Cdk1 also stopped DNA repair.
特异的信号基序不仅包括蛋白激酶可以识别的序列(1),也包括那些能够被磷酸化依赖结合蛋白如14-3-3识别的序列(2)。
Specific signaling motifs include not only sequences that are recognized by protein kinases (1), but also those that are recognized by phosphorylation-dependent binding proteins such as 14-3-3 (2).
细胞分裂周期运行和不同时相的转换通过CDC25磷酸酶去磷酸化和激活周期蛋白依赖性激酶(CDK)复合物来调控。
Cell Cycle Progression through the cell division cycle and transitions between various phases are regulated by using CDC25 phosphatases to activate specific cyclin-dependent kinase(CDK) complexes.
目的探讨翼状胬肉组织中细胞周期蛋白依赖性激酶抑制剂P16的表达,了解其在翼状胬肉发病机制中的作用。
Objective To observe the expression of cyclin kinase inhibitor P16 in pterygium and to investigate its effects on the pathogenesis of pterygium.
目的研究DNA依赖性蛋白激酶(DNA- PK)活性和脑胶质瘤化疗敏感性的关系。
Objective To investigate the relationship between DNA-dependent protein kinase (DNA-PK) activity and anti-cancer drug sensitivity in human glioma tissues.
目的探讨乳腺癌组织中DNA依赖蛋白激酶(DNA-PK)的表达变化及其意义。
Objective To investigate the expression change of DNA-PK in breast cancer tissue and the clinical significance.
目的观察细胞周期蛋白依赖性激酶- 2 (CDK - 2)在SH -SY5Y细胞中的表达情况。
Objective To investigate the expression of cyclin-dependent kinase-2 (CDK-2) gene in SH-SY5Y cells.
他们发现,由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。
They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.
在植物中a型和B型细胞周期蛋白依赖性激酶直接参与调控细胞周期。
In plants, a - and B-type CDKs are directly involved in cell cycle regulation.
结论翼状胬肉中细胞周期蛋白依赖性激酶抑制剂p16的低表达可能导致翼状胬肉细胞周期紊乱,其增殖失去控制。
Conclusion The lower expression of cell circle related kinase inhibitor in pterygium may play an important role on proliferation and pathogenesis of pterygium.
主要观察指标:神经细丝的磷酸化程度及糖原合酶激酶3、细胞周期依赖性蛋白激酶5的酶活性。
MAIN OUTCOME MEASURES: The degree of NF phosphorylation and the activities of GSK-3 and CDK-5 were mainly observed.
主要观察指标:神经细丝的磷酸化程度及糖原合酶激酶3、细胞周期依赖性蛋白激酶5的酶活性。
MAIN OUTCOME MEASURES: The degree of NF phosphorylation and the activities of GSK-3 and CDK-5 were mainly observed.
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