目的提高药物难治性癫痫癫痫灶的精确定位和手术方法恰当选择的水平。
Objective To promote the level of accurate localization and appropriate treatment of surgeon of refractory epilepsy.
结果药物难治性癫痫患者组脑内MRP1的表达显著高于正常对照组（P<0.01）。
Results Compared with the control group, MRP1 expression in brain specimens of medically intractable epilepsy patients showed an obviously statistical increasing(P<0.01).
因此研究难治性癫痫对抗癫痫药物产生耐药的原因，并谋求新的治疗措施，具有长远的意义。
Therefore to investigate the drug resistance mechanism of refractory epilepsy, and develop new strategies for treatment may have the deep influence in future.
目的建立大鼠难治性癫痫模型并观察其特点及研究多药物耐药蛋白P-糖蛋白表达规律，探讨癫痫耐药机制。
ObjectiveTo establish and research the rat model of refractory epilepsy and investigate the rule of P-glycoprotein expression to make the mechanism of drug resistance clear.
讨论：药物难治性的颞叶癫痫症或潜在疾病是语言延迟发育显著的高危因素。
DISCUSSION: Pharmacologically intractable epilepsy of the temporal lobe, or the underlying condition, is a significant risk factor for delayed language development.
讨论：药物难治性的颞叶癫痫症或潜在疾病是语言延迟发育显著的高危因素。
DISCUSSION: Pharmacologically intractable epilepsy of the temporal lobe, or the underlying condition, is a significant risk factor for delayed language development.
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