增加药物溶解度和溶出速率,是齐墩果酸新制剂研究中的主要措施。
One of the most powerful means in the development of oleanolic acid new dosage forms is to increase its solubility and drug dissolution velocity.
纳米粒静注给药不仅能提高药物溶解度,还具有给药体积小等优点,因而药物静注纳米混悬剂的研发日趋增多。
Nanoparticles not only enhance the solubility of drug, but also lower the volume of injection. These have led to increasing research and development activities for intravenous nanosuspensions.
介绍了静脉注射用脂肪乳剂在提高药物溶解度和稳定性、减轻药物不良反应、缓释、靶向给药和基因治疗等方面的研究进展。
The progress of drug loaded intravenous lipid emulsions in enhancing drug solubility and stability, reducing side effects, sustained release, targeted delivery and gene therapy is introduced.
表面活性剂通过增加药物的吸湿性、溶解度和分散性来增加其溶解速率。
Surfactants increase the dissolution rate by increasing the wetability, solubility, and dispersibility of the drug.
结果通过一些特殊的传递方法与策略,可以解决喜树碱类药物所存在的溶解度、稳定性、毒性和不良反应等问题。
Result the problems of camptothecin such as solubility, stability and side effects could be solved by special delivery methods and strategies.
大分子载体系统可以被用来提高这些这些药物的溶解度。
MacromoIecular carriers can be used to augment the solubility of such drugs.
目的:通过对诺氟沙星-PVP共沉淀物的研究,为提高难溶性药物溶出度和增大溶解度提供一些参考。
Objective: The authors studied norfloxacin PVP coprecipitate in order to provide references for difficult soluble drug to improve dissolution.
由于CH331是一种新型抗癌药物,对其性质研究的报道几乎没有,因此首先测定了其在不同介质中的溶解度以达到更好的包封效果。
Since CH331 is a novel antitumor agent, data is lacking on its physical and chemical character. It is necessary to study its solubility in different media for effective encapsulation.
药物的水溶解度与其吸收密切相关。
There exists an important relationship between the water solubility of drugs and their absorption.
结果:同一药物的不同晶型粉,显示出各自不同的结构图形、溶解度及生物有效度的特性。
Results:Each polymorphic form solid has it's x ray powder diffraction pattern and this different solid form shows different stability, formulability and bioavailability.
纳米混悬液可增大难溶性药物的溶解度,提高药物的有效性和安全性等。
Nanosuspensions not only solve the problems of poor solubility and bioavailability but also improve the efficacy and safety of drugs.
纳米混悬液可增大难溶性药物的溶解度,提高药物的有效性和安全性等。
Nanosuspensions not only solve the problems of poor solubility and bioavailability but also improve the efficacy and safety of drugs.
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