总结了路易斯酸在各种药物合成反应中的催化作用。
This paper gave an overall review of the application of lewis acid catalytic on various drug synthesis.
但是含氟药物合成反应的溶剂用量大，回收不完全，从而污染环境。
But the synthetic reaction needs large quantity of solvent and the recovery of solvent can not be complete.
结论：结合制药工程专业特色进行药物合成反应教学，有助于教学效果的提高。
Conclusion: Performing the teaching of drug synthetic reactions combined with the characteristics of pharmaceutical engineering is helpful to increase the teaching effects.
方法：四种药物通过酯化、酰胺反应由不同的连接子合成酰胺类和混合键类互联体前药。
Methods: Amide and mix-type bonds compounds were synthesized by conjugated the amino groups and acid groups with hydroxyl or acid links.
以对甲酚为原料经溴化、水解、甲氧基化和甲基化4步反应合成药物中间体3，4，5-三甲氧基苯甲醛，总收率达53。
The 3,4,5 trimethoxybenzaldehyde is synthesized from p cresol in four steps of bromination, hydrolyzation, methoxylation, and methylation, with an overall yield of 53.
和其他化学合成类药物不同的是，大多数细胞因子引起的药物不良反应和其本身的生物学活性有关。
Different from other chemosynthesis drugs, the adverse reactions caused by most reconstituted cytokinesis due to biology activity of themselves.
本文从氟康唑的抗真菌作用机制，药物动力学，临床应用范围，不良反应及氟康唑衍生物的合成等方面的研究进展进行了综述。
The progress in researching of fluconazole mechanism of ation, pharmacokinetic, clinical application patterns, side effects and synthesis of fluconazole derivatives was reviewed in this paper.
反应具有操作简便、对映选择性高等优点，反应产物可以用于很多手性药物和天然产物的合成中。
The reaction has the advantages of convenient operation, high enantioselectivity, and the like, and a reaction product can be used for the synthesis of many chiral medicaments and natural products.
反应具有操作简便、对映选择性高等优点，反应产物可以用于很多手性药物和天然产物的合成中。
The reaction has the advantages of convenient operation, high enantioselectivity, and the like, and a reaction product can be used for the synthesis of many chiral medicaments and natural products.
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