结论：纽蛋白和线粒体顺乌头酸酶参与细胞损伤，可能成为神经防护药物作用的靶点。
Conclusion Vinculin and mitochondrial aconitase may be involved in the cytotoxicity, which may be the target of neuroprotective drugs.
然而这些行为正是当前药物作用的靶点，因此，该细胞中的艾滋病病毒可以免于被药物杀伤。
However, these ACTS is the role of the current drug targets, so that the cells of HIV can be free from anti-drug.
柯西奥期待这些文章能够促使研究关注于对胆固醇对眼睛的作用问题上，这可以帮助科学家确定潜在的药物靶点。
Curcio anticipates that these papers will prompt more research aimed at understanding the role of cholesterol in the eye, which could help scientists identify potential drug targets.
首次发现作用于细菌外壁令人琢磨不透的药物靶点详尽图像给科学家提供足够的新信息以帮助设计新型抗生素。
The first detailed images of an elusive drug target on the outer wall of bacteria may provide scientists with enough new information to aid design of novel antibiotics.
但是不管时间有多长，任何药物的结构改变都会改变他们对靶点的作用能力。
Any alteration of a drug's structure, however, will change its ability to interact with its target, regardless of the length of time involved.
下一步是试图去证实，在增高的风险中，这些基因中的每一个起多么重要的作用，最终，他说，此发现可能为新药物的研究提供靶点。
The next step is to try to identify how great a role each of these genes play in raising risks. Ultimately, he said, the findings might offer a target for new drugs.
因此比起当前的镇痛药物，针对该靶点的新药将提供低副作用的新疼痛疗法。
As such, new drugs targeting this protein could herald a new class of pain treatments with many fewer side effects than our current drugs for pain.
另外，我们也特别列举了一大类的非癌基因证据，它们有时往往可以作为治疗肿瘤的药物作用靶点。
In particular, we present evidence for a large class of non-oncogenes that are essential for cancer cell survival and present attractive drug targets.
这些被抑制和被激活的蛋白可能为肿瘤生物标志物和药物作用靶点，为肿瘤的诊断和治疗提供了新的候选蛋白。
These repressed or activated proteins were the potential tumor biomarkers and drug targets, which would offer the candidate proteins for tumor diagnosis and treatments.
我们利用药物的表型副作用相似性来推断，是否两种药物作用于同一靶点。
We used phenotypic side-effect similarities to infer whether two drugs share a target.
近几年，人们发现了几种新的药物作用靶点，通过对这些新靶点的研究，有望开发出更安全有效的调脂药物。
Recently some new targets in the process of lipid metabolism were found, they may lead to the development of new drugs.
血管内皮细胞乙酰胆碱作用靶标(ETA)作为特异性血管内皮细胞药物作用新靶点具有良好的抗动脉粥样硬化应用前景。
Endothelial target for acetylcholine (ETA) plays an important role in preventing atherosclerosis, and it may be a unique molecular target of the novel drugs against atherosclerosis.
对老药作用机制的广泛的研究将为新近发现的药物靶点提供更多的证据。
Intensive study of the mechanisms of action of older drugs has provided further validation of several recently identified drug targets.
药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。
The genetic polymorphism of drug metabolizing enzyme, transporter and target greatly influence the individual difference of drug efficiency and toxicity.
大多数有效的药物靶点能够通过蛋白质相互作用网络分析，在大量非同源蛋白质间识别。
Most potent drug target can be identifying among large number of non-homologous protein through protein interaction network analysis.
多靶点药物可以同时调节疾病网络系统中的多个环节，不易产生抗药性，对各靶点的作用产生协同效应，达到最佳的治疗效果。
Multi- target therapeutics which regulates multiple nodes of the disease network simultaneously shows synergistic effect, is unlikely to induce resistance and provides optimal clinical use.
这些证据都提示该受体可能是重要的抗精神病药物作用靶点。
These lines of evidence implicate a role of this receptor as an important target for antipsychotic drugs.
作为一种刺激信号，药物也能够在不同的微环境及病理状态下通过不同的作用靶点产生不同的治疗效果。
As a stimulatory signal, drug can also produce different therapeutic effects through the different targets according to different microenvironment and pathologic state.
随着对肿瘤发生机制研究的深入，作用于细胞信号转导通路的药物开始引起研究者的关注，成为抗肿瘤药物研发的重要靶点之一。
With the thorough research of tumor mechanism, drugs acting on cell signal transduction pathway began to attract attention of researchers as an important target for anticancer drug development.
这一治疗方案能够防止HIV 病毒耐药株的产生，减少单一作用靶点药物的用药剂量和降低相应的毒性，最终治愈AIDS相关的病理学变化。
This approach could prevent the development of drug-resistant HIV strains and decrease the dosage and related toxicity of each single drug and lead to a cure for AIDS-associated pathologies.
Ray表示：“这真是一个好事情，短肽的作用靶点恰好是一个非常保守的区域，非常有希望成为药物候选。”
"The really good thing is that it targets a very conserved area," says Ray. "it does seem to be a promising candidate."
来自EMBL的一个研究团队开发了一种计算方法，通过比较药物的副作用来看看能否预测药物的作用靶点。
A team of EMBL researchers now developed a computational tool that compares side effects to test if they can predict common targets of drugs.
本文根据药物作用靶点和机制，以上述几类药物为主，综述了目前AD的药物研究进展。
In this paper, we review the current status of the drug development for AD, and mainly discuss the above-mentioned drugs which are classified according to their therapeutic targets.
由于目前的药物起效慢和不良反应多，临床疗效仍不满意，多靶点、多系统共同作用类药物已成为新的研究方向。
They still can not meet clinical needs with respect to both efficacy and side effects. A diversity of multi-target strategies are proposed for the future generation of successful antidepressants.
本文以风湿性疾病常用的治疗药物为主线，归纳了近年来影响药物疗效中有关药物代谢酶、药物转运体和药物作用靶点的基因组学研究进展。
The progress of pharmacogenomic research in the effects of drug treatment on rheumatic diseases could prevent adverse reactions, and provide reasonable guidance to clinical treatment.
腺苷受体可能成为脑缺血时药物作用的新靶点。
Thus, adenosine receptors may become new pharmacological targets in cerebral ischemia.
目前，人们对白色念珠菌的研究主要集中在弄清其致病机理和发现新的药物作用靶点。
Recent studies on C. albicans have been focused on understanding its pathogenesis and on identifying therapeutic targets for the development of novel antifungal drugs.
对DNA的研究是生命科学研究中一个极其重要的方面，在药物筛选和药物设计中它是重要的作用靶点。
It is an important biological target in the drug screening and drug designing. Lots of anticancer drugs and antiviral drugs had effects on DNA.
随着对糖尿病发病机制研究的深入，糖尿病药物研究也从对传统机制的药物研究过渡到对具有新作用靶点和新作用机制的药物研究。
With the advance of the pathogenesis of diabetes research, the study of diabetes drugs has transformed from the traditional antidiabetic drugs to the drugs which have new targets and new mechanism.
鉴于Chk1的抑制作用能够引起许多肿瘤细胞系的死亡，它已经成为肿瘤治疗中心的药物靶点(9)。
Chk1 has emerged as a drug target for cancer therapy as its inhibition leads to cell death in many cancer cell lines (9).
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