药物代谢研究是新药开发中不可缺少的一项。
Metabolic study is an indispensable part to the development of new drugs.
目的：建立一种简便、经济、高效分离原代大鼠肝细胞的方法，适用于体外药物代谢研究。
Objective: to develop a convenient, inexpensive and efficient method for isolation of functional primary rat hepatocytes, which can be used successfully for in vitro metabolism study.
巴格列酮已经经过一系列临床前期药效药理学、安全药理学、药代动力学或毒性动力学和药物代谢研究的评估。
Balaglitazone has been evaluated in a series of preclinical efficacy pharmacology, safety pharmacology, pharmacokinetic/toxicokinetic, and drug metabolism studies.
综述了目前HPLC-NMR联用技术在药物代谢研究，天然产物分析以及食品分析等方面的应用。
The application of HPLC-NMR in drug metabolism, natural products analysis and food analysis were reviewed.
人们越来越多的意识到，其应该认真研究肥胖以及其他因素对药物的吸收、分布、代谢和其他方面的影响。
There's a growing awareness that we need to more carefully consider obesity and other factors that affect drug absorption, distribution, metabolism and other factors.
并不是所有物种都伴随有衰老的现象。一些研究表明通过使用某些药物或者改善饮食结构可以减速生物的新陈代谢以及改变基本的衰老过程，以此来帮助我们延年益寿。
Not every species ages, and some research suggests that drugs or changes in diet may slow metabolism or alter basic aging processes so that we can live longer.
目的：为了促进药物代谢酶在临床上的深入研究。
Objective: To promote the study of drug metabolic enzymes in clinical practice.
根据少数关于柚子对药物代谢影响的研究，看起来柚子和柚子汁像葡萄柚和葡萄柚汁一样起作用。
From the handful of studies on the effects of pomelo on drug metabolism, it looks like pomelo and pomelo juice act much like grapefruit and grapefruit juice.
研究人员称这种代谢过程能够最终没有副作用风险的使医生找到适合患者的完美药物。
The researchers say this kind of "metabolic profiling" could ultimately allow doctors to work out perfect drug matches for individuals, with no risk of side effects.
微循环作为机体最小的循环单位，极大地影响纳米药物的运输、代谢，成为纳米医学研究的重要平台；
As the least circulatory unit, microcirculation affects the delivery and metabolism of drugs greatly, and has become the important responsive stage of nanomedicine research.
然而IL - 1受体拮抗剂治疗骨关节炎的临床实验仅取得有限成功，研究人员认为主要是因为药物代谢太快。
However, trials of IL1RA for osteoarthritis have had limited success, primarily because the drug tends to break down quickly, according to the researchers.
根据动物实验来预测人体的药物代谢时，代谢酶的种属差异性会使这项研究工作变得非常困难。
Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes.
多年来，对细胞色素酶P 4 5 0的研究主要集中在其代谢外源性药物和毒物的方面。
For many years, researches on Cytochrome P450 had been focused on their roles in exogenous drugs and poisons metabolism.
对于这种多成分组成的药物的代谢过程，以往较少有人去系统地研究。
By now quite few studies on the metabolic process of such medicines as made up of multi-constituents have been carried out systematically.
苷类是天然药物代谢的研究重点。
Glycosides are research focal point of natural drugs 'metabolism.
肝亚细胞成分是研究药物代谢及种属差异的较好体外模型。
The results suggest that hepatic subcellular fractions are useful as in vitro models for species difference study.
目的：综述近年来中药有效成分对药物代谢酶的影响的研究进展。
Objective: To review the effects of the active components of Chinese herbs on drug metabolizing enzymes.
目的研究酮康唑对沙奎那韦的体外代谢和药物代谢动力学的影响。
Aim to investigate the effect of ketoconazole on the metabolism in vitro and pharmacokinetics of saquinavir.
结论：药物代谢酶的认识和研究有助于临床合理用药和减少药物不良反应。
Conclusion: the study of drug metabolic enzymes will help to provide safe, rational and effective prescriptions and to decrease the adverse drug reactions.
结论杆状病毒表达系统能成功表达有活性的CYP2B6重组酶，可用来进一步研究在药物代谢中的作用。
CONCLUSION Active recombinant human CYP2B6 obtained using baculovirus expression system will facilitate further examination of the role of this enzyme in drug metabolism.
目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。
Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.
据研究人员推测，棕色脂肪可能被针对特定部分棕色脂肪代谢途径的药物所激活。
Researchers speculate that brown fat could be activated by a drug targeted at particular parts of brown fat's metabolic pathways.
这些试验中的相关的药物代谢动力学和机械学的研究将会考虑到优化药物定量和监测。
Linked pharmacokinetic and mechanistic studies within these trials will allow for optimizing drug dosing and monitoring.
这份新指南反映了FDA内分泌与代谢药物咨询委员会的决定，该委员会7月份时曾要求对新糖尿病药物(可能导致)的心血管病风险进行研究。
The new guidance reflects the decision of the FDA's Endocrinologic and Metabolic drugs Advisory Committee, which in July called for studies of the cardiovascular risks of new diabetic drugs.
体外培养的原代肝细胞被广泛用于药物代谢、药物间相互作用和药物肝毒性的研究。
Primary cultures of hepatocytes have been extensively used for evaluation of drug metabolism, drug-drug interactions and drug hepatotoxicities.
本文以风湿性疾病常用的治疗药物为主线，归纳了近年来影响药物疗效中有关药物代谢酶、药物转运体和药物作用靶点的基因组学研究进展。
The progress of pharmacogenomic research in the effects of drug treatment on rheumatic diseases could prevent adverse reactions, and provide reasonable guidance to clinical treatment.
探索高通量分析方法，进行氨基寡糖系列化合物的结构与代谢研究、药物动力学多合一筛选。
In exploring of high-throughput pharmacokinetic study, we profiled the isovalertatine family aminooligosaccharides and tried the cassette dosing in pharmacokinetic screening of drug candidates.
摘要 ：本文简要综述了蟾毒它灵的相关研究进展，其研究主要集中在提取分离、抗肿瘤作用机理、药物代谢动力学、毒性及合成等方面。
Abstract : This paper reviews the research progress on bufotalin. It mainly focused on extraction and isolation, anti-tumor mechanism, pharmacokinetics, toxicity, synthetic and so on.
摘要 ：本文简要综述了蟾毒它灵的相关研究进展，其研究主要集中在提取分离、抗肿瘤作用机理、药物代谢动力学、毒性及合成等方面。
Abstract : This paper reviews the research progress on bufotalin. It mainly focused on extraction and isolation, anti-tumor mechanism, pharmacokinetics, toxicity, synthetic and so on.
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