目的：研究限食对脂肪组织胰岛素信号通路基因表达的影响。
Objective: To study the influence of dietary restriction on the expression of insulin signaling pathway genes in mouse adipose tissue.
然而为了让它们有效，需要确定是哪一条胰岛素信号通路将被激活。
However in order for them to be effect you would have to ascertain which insulin signal pathway will activate.
与之相反的是，游离脂肪酸处理24小时与胰岛素信号通路的下调有关。
In contrast, FA treatment for 24 hours was associated with decreased insulin signaling.
PTP1B在胰岛素信号通路中起着重要的负调控作用，是治疗糖尿病和肥胖症的新靶点。
PTP1B plays an important role in the negative regulation of insulin signaling pathway. It has been proved to be a novel target for diabetes and obesity.
通过应用PPAR，他们能够绕过损伤的胰岛素信号通路，使得需要胰岛素的细胞得以存活。
However, by administering PPAR, they were able to bypass the defects in insulin signaling and preserve the cells that need insulin to thrive.
寻找PTP1B的特异性抑制剂，通过抑制PTP1B的活性来提高胰岛素信号通路的敏感性，对糖尿病和肥胖症治疗有着重要的应用前景。
Inhibition of PTP1B's activity could improve the sensitivity of insulin signaling. The discovery of highly effective inhibitors of PTP1B has a promising application in diabetes and obesity therapy.
在脊椎动物中，IRS-2以脚手架蛋白发挥作用，协调胰岛素/IGF信号级联通路中的不同分支（2）。
In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades (2).
它既可以作为整合各种信号转导通路的上游信号如胰岛素、生长因子和有丝分裂原的整合器，又可以作为感知细胞内营养与能量水平及还原状态的感受器。
It combines input from multiple upstream pathways, including insulin, growth factors and mitogens while functioning as a sensor of cellular nutrient and energy levels and redox status.
胰岛素信号转导通路对神经元存活有一定作用。
The insulin signaling pathway could affect the survival of the neurons in rats' hippocampus.
胰岛素的这种作用与IRS1信号转导通路密切相关。
The effect of insulin is highly associated with IRS1 signaling cascades.
这个新的通路不依赖于胰岛素信号传递系统，他们说，虽然这个通路与其他基因有共同的遗传基础，但是该通路只对饥饿起反应。
This new pathway works independently of the insulin-signaling pathway, they said, although it shares several genetic elements, and is dedicated just to the famine response.
结论：ROS、PTEN及P -AKT参与了葡萄糖刺激INS - 1细胞分泌胰岛素的信号通路，成为介导胰岛素分泌的信号分子。
Conclusion: ROS, PTEN and p-AKT are involved in the signaling pathway of glucose-stimulated insulin secretion in INS-1cell, as signaling molecules in insulin secretion.
结论：ROS、PTEN及P -AKT参与了葡萄糖刺激INS - 1细胞分泌胰岛素的信号通路，成为介导胰岛素分泌的信号分子。
Conclusion: ROS, PTEN and p-AKT are involved in the signaling pathway of glucose-stimulated insulin secretion in INS-1cell, as signaling molecules in insulin secretion.
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