目的设计、合成并筛选具有胆碱能活性,且对M1受体有选择性的莨菪烷衍生物。
OBJECTIVE to synthesize and screen tropane derivatives with cholinergic activity and subtype-selectivity of M1 receptor.
进一步发现,各组外周脾淋巴细胞膜胆碱能受体活性的改变与脑内变化一致。
Similar changes were found in the binding activities of M-and N-receptors on spleen lymphocytes.
该药促进学习记忆的机制可能是,(1)增强中枢胆碱能系统的活性;
The mechanisms may be 1. increasing the activity of the cholinergic system of CNS;
该药促进学习记忆的机制可能是,(1)增强中枢胆碱能系统的活性;
The mechanisms may be 1. increasing the activity of the cholinergic system of CNS;
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