胃内漂浮制剂,亦称漂浮药物输送系统,是延长药物胃内滞留时间的一种制剂。
Floating drug delivery system (FDDS) is one of the approaches to increase the retention time of an oral dosage form in the stomach.
目的优选左金丸胃内漂浮缓释片的制剂配方。
Objective To screen out an optimum pharmaceutical formulation of intra-gastric floating sustained-release tablet of Zuojin Pills (IFTZ).
该制剂口服后可以维持自身密度小于胃内容物密度,从而较长时间在胃中呈漂浮状态,而不受胃排空速率的影响。
FDDS have a bulk density lower than gastric fluids and thus remain buoyancy in the stomach without affecting the gastric emptying rate for a prolonged period of time.
该制剂口服后可以维持自身密度小于胃内容物密度,从而较长时间在胃中呈漂浮状态,而不受胃排空速率的影响。
FDDS have a bulk density lower than gastric fluids and thus remain buoyancy in the stomach without affecting the gastric emptying rate for a prolonged period of time.
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