血管形成是实体肿瘤增殖和转移的关键步骤，这一过程依赖于内源性刺激因子和抑制因子之间的平衡。
Angiogenesis is the key step in tumors proliferation and metastasis, which depends on the net balance between endogenous stimulators and inhibitors.
TGF配体虽然在早期肿瘤中作为肿瘤抑制基因发挥作用，但其在进展期肿瘤中却变成有效的促转移因子。
TGF ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers.
肿瘤血管生成是肿瘤生长转移的关键步骤，是促血管生成因子和抑制因子作用失衡的结果。
Tumor angiogenesis, resulting from the imbalance of angiogenic cytokines and angiogenesis inhibitors, is crucial for tumor growth and metastasis.
目的研究壳寡糖对小鼠肿瘤生长和转移的抑制作用以及壳寡糖对培养的巨噬细胞相关的细胞因子表达的影响。
Objective to study the influence of oligochitosan in inhibiting growth and metastasis of tumor in rats, and in expression of cytokines associated with macrophage.
结论壳寡糖具有良好抑制肿瘤生长和转移的作用。壳寡糖可增强巨噬细胞相关的细胞因子表达。
Conclusion Oligochitosan can inhibit growth and metastasis of tumor, and enhance expression of cytokines associated with macrophage.
结论壳寡糖具有良好抑制肿瘤生长和转移的作用。壳寡糖可增强巨噬细胞相关的细胞因子表达。
Conclusion Oligochitosan can inhibit growth and metastasis of tumor, and enhance expression of cytokines associated with macrophage.
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