目的：探讨消化道肿瘤的多药耐药机制和逆转策略。
Aims: To study the multi-drug resistance mechanism of digestive tract tumors and its reverse strategy.
肿瘤的多药耐药性是导致临床化疗失败最主要的原因。
The1 main reason of the failure in the cancer clinical chemotherapy is multidrug-resistance.
中药资源丰富，作用靶点多，可针对多药耐药机制复杂的特点，现有研究亦提示开发中药肿瘤多药耐药逆转剂有较好的前景。
And many researchers pay attention to natural drugs. Traditional Chinese medicine has plentiful resource and multitarget, and it can aim directly to the complicated mechanisms of MDR.
目的研究川芎嗪脂质体在体外对肿瘤细胞的细胞毒作用和对多药耐药的逆转作用，并研究脂质体剂型对上述作用的影响。
Objective: to study the cytotoxic effect of ligustrazine liposomes on tumor cell in vitro and the reversing effect on the MDR, and explore the influence of dosage form on the above effects.
本文综述了谷胱甘肽及其相关酶系统在肿瘤多药耐药中的作用，介导多药耐药的可能机制以及谷胱甘肽类似物结构与转运活性的关系。
We introduced the effects on MDR, the possible mechanisms of glutathione and related enzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper.
近年研究发现容积调控性氯通道与肿瘤细胞的增殖、侵袭、迁移、凋亡及多药耐药性等恶性生物学行为有关。
In recent years, it has been realized that volume-regulated chloride channels are closely associated with proliferation, invasion, migration, apoptosis and multi drug resistance of tumor cells.
本文通过实验方法研究设计和临床应用，探讨肿瘤多药耐药基因（MDR-1）的异常表达检测方法及其临床意义。
Through experimental method design and clinical application, this paper investigated the detecting method and clinical significance of multi-drug resistance gene (MDR-1) expression.
目前的研究发现，有多类细胞色素P 450酶与肿瘤多药耐药的发生密切相关。
In recent years, researches found that there were many kinds of cytochrome P450 enzymes which related to multidrug resistance of tumor.
药物递送系统是克服肿瘤多药耐药性(MDR)的一种新策略。
Drug delivery system (DDS) is a novel approach to overcome multidrug resistance (MDR) in tumors nowadays.
前言：观察三物白散加味方对肿瘤多药耐药(MDR)基因表达的影响。
To observe the effect of Modified "Sanwubai Powder" in affecting Multidrug resistance (MDR) gene expression of tumor.
目的：观察三物白散加味方对肿瘤多药耐药(MDR)基因表达的影响。
Objective To observe the effect of Modified Sanwubai Powder in affecting Multidrug resistance (MDR) gene expression of Tumor.
目的探讨食管癌患者肿瘤组织中多药耐药(MDR)基因表达及其在临床上的应用价值。
Objective To explore multidrug resistance (MDR) gene expression in tumor tissue of esophageal carcinoma and its application value in clinical.
结论P -糖蛋白介导的多药耐药是膀胱癌腔内灌注化疗失败、肿瘤复发的重要原因。
Conclusion the P-glycoprotein-mediated MDR may be an important cause of recurrent of bladder cancer after treated by perfusion chemotherapy.
肿瘤多药耐药的机制十分广泛，其中以ATP结合盒式结构超家族成员研究较多。
The mechanism of multidrug resistance is vary, while much attention was paid on the expression of ABC(ATP binding cassette) transporter.
肿瘤化疗失败的主要原因是多药耐药（MDR）的产生。
Multidrug resistance (MDR) of cancer cells is a major cause of failure in chemotherapy.
目的：研究瑞香狼毒（SC）小鼠药物血清与细胞毒化疗药物联合应用对K5 6 2 /VCR多药耐药细胞的协同抗肿瘤效应。
Objective:To study the synergistic antitumor effects of Stellera chamaejasme (SC) with cytotoxic chemotherapeutic agents on K562/VCR multi-drug resistance (MDR) cells.
文章重点综述目前研究较多的多药耐药机制，并对肿瘤耐药逆转进展作简要介绍。
This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.
逆转肿瘤细胞多药耐药旨在全部或部分恢复肿瘤细胞对化疗药物的敏感性，已成为肿瘤mdr研究的热点。
The aim of reversing MDR of gastric cancer cells is to entirely or partly recovery their chemotherapy to drugs, which has become a hot spot in solid tumor MDR research nowadays.
目的探讨本芴醇衍生物LY980 5 0 3对肿瘤多药耐药的逆转作用及其作用机理。
AIM To investigate the reversing effect of LY980503 (a benflumetol derivative) on multidrug resistance of MCF/Dox cell line and its mechanism.
临床化疗失败的重要原因是肿瘤细胞对化疗药物产生多药耐药（MDR）。
Multidrug resistance to chemotherapeutic drugs is an important reason for clinical chemotherapy failure.
临床化疗失败的重要原因是肿瘤细胞对化疗药物产生多药耐药（MDR）。
Multidrug resistance to chemotherapeutic drugs is an important reason for clinical chemotherapy failure.
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