由于该机制可影响特定抑癌基因的活性，因而与肿瘤形成密切相关。
This mechanism is particularly relevant in cancer since it can interfere with the activity of specific "suppressor" genes.
我们证明Chd5在活体中作为抑癌基因发挥作用而且在人类恶性肿瘤与CHD5的缺失有关。
We demonstrate that Chd5 functions as a tumor suppressor in vivo and implicate deletion of CHD5 in human cancer.
肿瘤形成与控制细胞生长和分化的多种基因特别是癌基因、抑癌基因的遗传改变有关。
There are multiple genes especially oncogenes and tumor suppressor genes involved in 'the genetic alterations which regulating the growth and differentiation of cells.
FHIT是一种重要的抑癌基因，在多种肿瘤中被发现表达缺失。
FHIT is an important tumor suppressor gene, in a variety of tumors expression was found missing.
因此，探讨不同类型肿瘤相关癌基因和抑癌基因是认识肿瘤发生分子机理、开展基因诊断和基因治疗的基本前提。
Therefore, the detection of oncogenes and TSGs in different tumors is the basic prerequisite to understand the mechanism of tumorigenesis and to conduct gene diagnosis and gene therapy.
虽然有事实证明一些微小rna能够起癌基因或者抑癌基因，但是其在肿瘤的侵袭和转移中的作用尚未有研究。
Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored.
越来越多的证据表明，肿瘤的发生是多因素作用的结果，与癌基因的激活与抑癌基因的失活有关。
More and more evidence indicated that the formation of tumor is due to multi factors with oncogene activation and anti oncogene inactivation.
肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
研究表明几乎一半人类肿瘤都存在抑癌基因的失活，可见抑癌基因失活与肿瘤生长有着密切的关系。
Studies have sh own that the anti oncogene inactivation was closely related to tumor development because of the findings of anti oncogene inactivation in nearly one half of human tumors.
其发生机制可能与肿瘤血管生成受阻、癌基因与抑癌基因、宿主免疫状态、肿瘤细胞增殖周期及信号传导有关。
The mechanism of tumor dormancy is related to hindrance of angiogenesis, oncogene and antioncogene, immunocompetence, proliferation cycle, signal conduction and so on.
目的：探讨壶腹癌中抑癌基因P16蛋白与增殖细胞核抗原（PCNA）表达的相关性及其与肿瘤临床病理特征的关系。
Objective:To study the expression of P16 protein and PCNA in ampullary carcinoma and its relation with its pathological features.
而某些癌基因和抑癌基因对HIF-1表达及活性的影响最终决定着肿瘤的预后。
The influencing of some oncogene and anti-oncogene to the expression and activity of HIF-1 determines neoplastic prognosis ultimately.
近来对新发现的肿瘤转移抑制基因NM 23和抑癌基因pten引起了人们极大关注。
Recently, the new discovered NM23 gene (a tumor metastasis suppressor gene) and PTEN gene (a tumor suppressor gene) cause people's attention extensively.
而肿瘤的发生与抑癌基因和癌基因密切相关。
And the occurrence of tumor is closely related to oncogenes and anti-oncogenes.
越来越多的研究发现FHIT基因在大量的原发性肿瘤及细胞株中存在异常，该基因被认为是一个候选的抑癌基因。
Abnormalities in the FHIT gene its expression have been identified in a variety of human cancer cell lines and tumors.
这太有趣了，肿瘤基因（抑癌基因和原癌基因）的表达与多细胞生物体在遗传发生层面的形态协同一致的。
It is of interest that the coordinated expression of "cancer genes" (tumor supressors and oncogenes) coincides with the appearance of multicellularity in the filogenetic scale.
人类肿瘤的发生是多基因、多步骤共同作用的结果，抑癌基因在这一进程中扮演着重要的角色。
Cancer in humans is the result of a multi-gene, the combined effect of multi-step process, and tumor-sup-pressor genes play an important role in this process.
目的探讨胃癌组织中甲基化酶、去甲基化酶基因与肿瘤相关癌基因和抑癌基因的关系。
Objective To investigate the relationship of the expression of DNA methyltransferase, demethylase(mbd2) and tumor-associated genes in human gastric cancer.
目的探讨胃癌组织中甲基化酶、去甲基化酶基因与肿瘤相关癌基因和抑癌基因的关系。
Objective To investigate the relationship of the expression of DNA methyltransferase, demethylase(mbd2) and tumor-associated genes in human gastric cancer.
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