肿瘤干细胞学说认为，肿瘤组织中也存在少量具有干细胞性质的肿瘤干细胞，肿瘤干细胞是肿瘤发生、转移和复发的关键。
The theory of cancer stem cell proposes that the tumor tissue has its own cancer stem cells in it and regards cancer stem cell as the key to regeneration, metastasis and recurrence.
然而，耶鲁研究小组发现这些突变不会共存于同意细胞内导致肿瘤发生。
However, the Yale team found that these mutations did not have to co-exist in the same cell to cause tumors.
在胰岛素抵抗的个体或2型糖尿病患者中，胰岛素的细胞内作用在肿瘤发生方面可有改变？
Are there any changes of insulin's intracellular function in individuals with insulin resistance or type 2 diabetes, in terms of cancer development?
以前科学家们不能确认癌症是否直接起源于干细胞，或子代细胞是否是肿瘤发生的根源。
Previously scientists could not be sure if the cancer causing faults occurred directly to stem cells, or whether 'daughter' cells were the route cause of the tumour.
这表明，在一定程度上恶性肿瘤的生长依赖于后生因素，而后生因素又被肿瘤发生中细胞间的联系所控制。
This suggests that, to some extent, malignant growth depends on epigenetic factors that are governed by the cellular context in which a tumor arises.
我们在乳腺癌细胞中筛选与肿瘤发生相关的DNA。
We screened the DNA from breast cancer cells for amplifications that are associated with tumor development.
HHV-6感染与口腔恶性肿瘤之间存在相关性，可能参与肿瘤发生、细胞癌变的过程。
The infection of HHV-6 correlates to oral malignancy, which suggests HHV-6 may play a role in the occurrence and cell transformation of malignancy.
目的：检测BLU与ARF基因启动子在鼻NK/T细胞淋巴瘤中的甲基化状态，探讨其在肿瘤发生中的作用与分子病理诊断中的应用价值。
AIM: To investigate the hypermethylation of the BLU and ARF promoter in nasal NK/T cell lymphoma from nasopharyngeal mucosa and its roles in tumor genesis and molecular pathological diagnosis.
端粒酶激活可以维持增殖细胞染色体的稳定性，导致细胞永生化和肿瘤发生。
Telomerase activation is essential for the stabilization of chromosomes in proliferation cells, leading to cellular immortality and oncogenesis.
细胞老化可能促进生物衰老，并且与肿瘤发生受抑密切相关。
Cellular senescence may contribute to the ageing of organisms, and is closely related to tumor suppression.
端粒酶的主要功能是复制端粒末端dna，维持端粒长度。端粒酶活性调节与肿瘤发生和细胞衰老有着密切关系。
The main function of telomerase is for the replication of telomere DNA, which is closely related with tumor and cell senescence.
目的：即往人们认为肿瘤发生的原因是细胞增殖分化异常而导致的细胞增殖过度。
Objective: Formerly people considered the reason of tumor happen is cell proliferate and differentiate abnormality to result in cell proliferate exorbitant.
细胞间隙连接通讯(GJ IC)与肿瘤发生密切相关，大多肿瘤细胞的GJIC功能微弱或缺失。
Intercellular space connection communication (GJIC) and the tumor have the close correlation, mostly tumor cell GJIC function weak or flaw.
癌基因，肿瘤抑制基因的发现促进了对细胞周期及细胞凋亡机制的深入理解。使人们对肿瘤发生和发展的认识也日趋深入。
The discovery of oncogene and tumor suppressor gene has deepened human beings understanding of the mechanisms of cell cycle and cell apoptosis as well as the mechanisms of tumorigenesis.
随着对肿瘤发生机制研究的深入，作用于细胞信号转导通路的药物开始引起研究者的关注，成为抗肿瘤药物研发的重要靶点之一。
With the thorough research of tumor mechanism, drugs acting on cell signal transduction pathway began to attract attention of researchers as an important target for anticancer drug development.
许田实验室研究人员曾研究发现这2个基因在同一细胞内能诱发恶性肿瘤发生。
Researchers in the Xu lab previously showed that a combination of the two within the same cell could trigger malignant tumors.
细胞凋亡过程阻滞与细胞增殖异常一样，是肿瘤发生的主要机制之一。
The block of cell apoptosis is one of the important mechanisms as the same as the abnormality of cell proliferation in carcinogenesis.
在肿瘤发生中，PIAS蛋白的过表达能抑制癌细胞的增殖并诱导其凋亡。
In tumor, overexpression of PIAS can inhibit the proliferation of cancer cells and induce cell apoptosis.
结论磷酸化酪氨酸蛋白可以促进NSCLC细胞的增殖生长，是NSCLC肿瘤发生的重要途径之一。
Conslusions The phosphotyrosine protein can promote NSCLC multiplication and growth, which is one of significant pathways that lead to NSCLC development and progression.
用分子细胞生物学、生物化学、遗传学等手段研究肿瘤细胞内的信号传导通路与肿瘤发生机理；筛选肿瘤治疗特异性靶标与新药开发。
Using molecular cell biology, biochemistry, genetics and other approaches to study the signal transduction pathways in cancers and establish tumor targeting strategy for drug development.
转移抑制基因是一类只抑制癌细胞的转移但不影响肿瘤发生和生长的基因。
Tumor metastasis suppressor genes is a kind of genes that only suppresses tumor metastasis without affecting tumorigenesis and tumor growth.
茶多酚与茶色素具有多种生物活性，除了抗氧化等作用外，还可以在肿瘤发生的各个阶段产生特定作用，从而抑制肿瘤细胞生长。
Tea polyphenols and tea pigment have many biological activities. They can inhibit tumor cell growth at the each stage of tumor development.
粒细胞弹性蛋白酶及其拮抗剂失衡是导致肿瘤发生的重要原因。
The imbalance between neutrophil elastase and neutrophil elastase inhibitor may be the cancer possible mechanisms of development.
现综述近年来有关上皮干细胞和肿瘤发生的关系及其调控机制方面的研究进展。
This article reviews the relationship and regulatory mechanism between normal stem cells and epithelial tumor stem cells.
现综述近年来有关上皮干细胞和肿瘤发生的关系及其调控机制方面的研究进展。
This article reviews the relationship and regulatory mechanism between normal stem cells and epithelial tumor stem cells.
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