肾间质疾病损伤机制及防治研究；
Study on mechanism and prevention of renal interstitial disease.
结果模型显示肾间质呈进行性纤维化。
Results a progressive fibrosis was observed in renal stroma of the model.
HE染色：假手术组肾小球，肾间质基本正常。
肾脏病理为急性肾小管坏死，肾间质炎症细胞浸润。
Renal biopsy revealed acute tubular necrosis and renal interstitial inflammation.
VDR表达的进行性减少提示其与肾间质纤维化有关。
The progression of decrease in expression of VDR indicates VDR may relate to renal interstitial fibrosis.
两组间肾小管、肾间质及肾血管积分差异无统计学意义。
There were no differences of tubulointerstitial lesions and arteriole hypertrophy between two groups.
所有病例均有不同程度的肾间质损害及肾小管功能的异常；
There were various injury of tubulointerstitium and the disfiguration of renal tubules in all cases.
肾间质纤维化是多种肾脏疾病走向肾功能衰竭的共同病理过程。
Renal interstitial fibrosis is the common pathological procedure to renal function failure of many kinds of renal diseases.
肾间质纤维化；肾小管上皮细胞；线粒体氧化损伤；肾小管功能。
Renal interstitial fibrosis; Renal tubular epithelial cell; Mitochondria oxidative damage; Renal tubular function.
目的：肾间质纤维化是多种肾脏疾病进展至终末期肾衰竭的共同通路。
Objective: renal interstitial fibrosis is the common way to final renal failure. Renal interstitial fibrosis play more dangerous role than glomerulosclerosis in the kidney.
结论1、醛固酮抑制对AA所致的慢性肾间质纤维化有一定的防治作用。
Conclusions1. Mineralocorticoid inhibition can prevent chronic renal interstitial fibrosis caused by AA.
术后9天处死各组大鼠，肾组织标本用PAS染色确证肾间质纤维化病变。
All the rats were sacrificed in 9 days, the kidneys were collected, and renal interstitial fibrosis was examined by PAS staining.
结论汉防己甲素、川芎嗪苦杏仁甙在预防及逆转肾间质纤维化中起重要作用。
Conclusion Tetrandrine, tetramethylpyrazine and amygdalin may play important roles in prevention and reversion of renal interstitial fibrosis.
目的观察鳖甲煎丸对肾间质纤维化实验大鼠肾脏的保护作用并探讨其作用机理。
Objective To observe the protective effect of Biejiajian Pills on experimental rat kidney from renal interstitial fibrosis and discuss the mechanism.
结论药典法定剂量的关木通水煎剂对大鼠肾功能及肾间质结构无明显的不利影响。
Condusion There is no significant adverse effect of CAM decoction on renal function and interstitial structure in rats at statutory dose according to pharmacopoeia.
目的：研究肾炎康复片对单侧输尿管梗阻(uuo)大鼠肾间质纤维化的保护作用。
Objective To study the protective effects of Shenyankangfu tablet on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO).
目的：探讨肾衰胶囊延缓慢性肾功能衰竭（CRF）进展及抗肾间质纤维化的机理。
Objective:To probe into the mechanism of Shenshuai Capsule in delaying advance of chronic renal failure(CRF)and against interstitial renal fibrosis.
显示肾小管功能检测对评价原发性肾小球疾病进展及肾间质损害程度具有重要的临床意义。
These findings suggest that detecting functions of renal tubules have important significances in estimating the development of PGD and the degree of damages in tubulointerstitium.
肾间质水肿伴炎症细胞浸润，部分小管上皮细胞变性、坏死并见管型，死亡率2 0 %。
The histologic changes of renal tissue were interstitial edema with inflammatory cellular infiltration, denaturalization and necrosis in some tubular epithelia. LPS caused 20% rats death.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。
Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结果在正常肾组织中，CD44在肾小球、肾小管无表达，肾间质可见CD44呈弱阳性表达。
Result Expression of CD44 in renal biopsy of controls was negative in the glomeruli and weakly positive in renal interstitium .
结论雌激素可能通过抑制UUO大鼠肾小管上皮细胞表型转化而发挥延缓肾间质纤维化的作用。
Estrogen can prevent the development of interstitial fibrosis, the mechanism may with it restrain the tubular epithelial cell phenotype transdifferentiation in UUO rats.
目的探讨替普瑞酮（GGA）对大鼠梗阻性肾病模型（UUO）肾间质纤维化的影响和可能机制。
Objective To investigate the effects of geranylgeranylacetone (GGA) on tubulointerstitiai fibrosis in unilateral ureteral obstruction (UUO) rats.
动物模型实验是研究肾间质纤维化必不可少的手段，实验者应根据不同的实验目的选择适当的动物模型。
The experiments on animal models are necessary for studying renal interstitial fibrosis. Researchers should find right animal models according to different objectives.
目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。
To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
在比利时，至少有70个人在不正确地采用马兜铃科草药作为助食品而需要肾移植或因肾间质纤维化而做透析。
In Belgium, at least 70 people required renal transplants or dialysis for interstitial fibrosis of the kidney after taking the wrong herb from the Aristolochiaceae family, again as a dietary aid.
目的：动态观察P 21在单侧输尿管梗阻肾间质纤维化大鼠模型中的表达，以及依那普利对其表达的调节。
Objective To investigate the expression of P21 in renal interstitial fibrosis rats and the effect of enalapril on it.
从上述过程不难看出细胞因子和肾间质细胞在肾间质纤维化中的重要作用，晚近大量研究资料也证实了这一点。
It's not difficult to see that cytokine and renal interstitial cells play a important role in RIF and recent study shows that too.
目的探讨表面活性蛋白A（SP-A）在肾组织中的表达部位及其表达变化与肾组织感染、肾间质炎症间的关系。
Objective To characterize the expression of surfactant protein A(SP-A) in normal and acute pyelonephritic rat kidneys and to study the correlation of infection and inflammation with SP-A expression.
目的探讨表面活性蛋白A（SP-A）在肾组织中的表达部位及其表达变化与肾组织感染、肾间质炎症间的关系。
Objective To characterize the expression of surfactant protein A(SP-A) in normal and acute pyelonephritic rat kidneys and to study the correlation of infection and inflammation with SP-A expression.
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