引起肾小管间质病变的原因比较复杂，其中蛋白尿的肾损伤作用已为大量临床和实验研究所证实。
The causes for tubulointerstitial changes remain rather complex and the role of proteinuria in damaging nephridial tissue has been demonstrated by large number of clinical and experimental studies.
结果：肾小球系膜区FN与系膜细胞增生、肾小球损伤程度及肾小管间质损伤程度均呈正相关。
Results Positive correlations were found between the degree of FN in glomerular mesangium or basement membranes and glomerular lesion grading or tubulointerstitial lesion grading.
肾间质纤维化；肾小管上皮细胞；线粒体氧化损伤；肾小管功能。
Renal interstitial fibrosis; Renal tubular epithelial cell; Mitochondria oxidative damage; Renal tubular function.
结论TIMP - 1过表达可通过增强炎症加重肾小管间质损伤。
Conclusions Overexpression of TIMP-1 exacerbates renal tubulointerstitial injury by enhancing inflammation.
单变量分析表明，血清肌酐水平、肾小球和肾小管间质损伤的严重程度都与高尿酸血症显著相关。
Univariate analysis showed that the level of serum creatinine and the severity of glomerular and tubular interstitial injury were significantly related to hyperuricemia.
单变量分析表明，血清肌酐水平、肾小球和肾小管间质损伤的严重程度都与高尿酸血症显著相关。
Univariate analysis showed that the level of serum creatinine and the severity of glomerular and tubular interstitial injury were significantly related to hyperuricemia.
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