P21可能参与肾小管间质纤维化的发病过程。
P21 may participate in the pathogenesis of renal tubule-interstitial fibrosis.
方法：采用单侧输尿管梗阻（UUO）诱导大鼠肾小管间质纤维化模型。
Method:Tubulointerstitial fibrosis model was established by unilateral ureteral obstruction(UUO) rat.
间质细胞增殖和凋亡失衡及细胞间质代谢失调也是造成肾小管间质纤维化的两个不可缺少的原因。
The imbalance of interstitial cell proliferation and apoptosis and the metabolic disorder of intercellular substance, are two essential factors for renal tubulointerstitial fibrosis.
结论激活素a能促进肾小管上皮细胞增殖、转分化，提示激活素a可能在肾小管间质纤维化中起重要作用。
Conclusions activin a can promote the proliferation and transdifferentiation of renal tubule cells, which suggests that activin a may play an important role in interstitial fibrosis of renal tubule.
结论雌激素可能通过抑制UUO大鼠肾小管上皮细胞表型转化而发挥延缓肾间质纤维化的作用。
Estrogen can prevent the development of interstitial fibrosis, the mechanism may with it restrain the tubular epithelial cell phenotype transdifferentiation in UUO rats.
肾间质纤维化；肾小管上皮细胞；线粒体氧化损伤；肾小管功能。
Renal interstitial fibrosis; Renal tubular epithelial cell; Mitochondria oxidative damage; Renal tubular function.
目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。
To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
模型组大鼠肾小管间质细胞增多，肾小管基底膜增厚皱缩，纤维化明显，随时间进展而加重；
The renal interstitial cells increased in rats of the model group with the basal membrane thickened and shrank as well as obvious fibrosis, which were aggravated with the time prolonging.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。
Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。
Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
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