结论COPD急性加重期较稳定期肺功能显著下降，肺过度充气和外周气道阻力增加是急性加重期肺功能恶化的主要原因。

Conclusions Pulmonary function of COPD decreased significantly from stable stage to exacerbation, the main reasons of which were hyperinflation and the increasing of peripheral airway resistance.

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因此，植入瓣膜组肺功能的改变可能不是由于肺充气过度减轻所致，而是其他未知的机制。

Thus, changes in lung function seen in patients with endobronchial valves may not be due to decreased hyperinflation but to other unknown mechanisms.

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因此，植入瓣膜组肺功能的改变可能不是由于肺充气过度减轻所致，而是其他未知的机制。

Thus, changes in lung function seen in patients with endobronchial valves may not be due to decreased hyperinflation but to other unknown mechanisms.

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