现将肥大细胞、蛋白酶激活受体- 2与肝纤维化的有关进展作一综述。
The following is a review of advances in mast cell, proteinase-activated receptor-2 and liver fibrosis.
糜酶是一类丝氨酸蛋白酶，主要存在于肥大细胞的分泌颗粒和细胞间质。
Chymase is a kind of serine proteinase, mainly exists in secretory granules of mast cell and extracellular Interstitium.
类糜蛋白酶是肥大细胞分泌的主要中性蛋白酶之一。
Chymase is one of the major proteases in the secretory granules of mast cells.
目的：探索中华眼镜蛇毒金属蛋白酶(MT)对人肥大细胞释放组胺的诱导作用及其机制。
AIM: to investigate the ability of Chinese cobra snake venom-metalloproteinase (MT) to induce the histamine release from human mast cells and its potential mechanisms.
而类胰蛋白酶受体激动剂对肥大细胞类胰蛋白酶分泌的促进作用则表明类胰蛋白酶是肥大细胞激活的正反馈性刺激剂。
Stimulation of tryptase release from mast cells by tryptase receptor agonists indicated that tryptase can stimulate mast cells in a positive feedback way.
SLPI能抑制中性粒细胞的弹性蛋白酶、组织蛋白酶g、肥大细胞的类糜蛋白酶、胰蛋白酶和糜蛋白酶，在变态反应性疾病和炎症中起重要作用。
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.
PAR - 2可能由肥大细胞分泌的类胰蛋白酶激活而参与非甾体抗炎药致小肠损伤的发病过程。
PAR-2 may be activated by tryptase released from mast cells and participate in the pathogenesis of small intestinal injury as induced by non-steroidal antiinflammatory drugs.
肥大细胞所释放的胰蛋白酶具有很强的生物活性，可能是进一步造成气喘中的发炎反应和气道过度反应。
Mast cell tryptase has potent biologic activities that may contribute to the inflammatory response and airway hyper-reactivity seen in asthma.
肥大细胞所释放的胰蛋白酶具有很强的生物活性，可能是进一步造成气喘中的发炎反应和气道过度反应。
Mast cell tryptase has potent biologic activities that may contribute to the inflammatory response and airway hyper-reactivity seen in asthma.
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