肝星状细胞是一种与肝纤维化密切相关的主要的细胞种类，它在肝受到损伤时形成瘢痕组织。
HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.
国际肝病：除了肝星状细胞在肝纤维化发生中的重要作用，还有哪些机制参与了肝纤维化的发生？
International Hepatology: Besides the important role of hepatic stellate cell in liver fibrosis development, are there any other important mechanisms involving liver fibrosis development?
在供体手术中，供体肝组织活检显示：门脉区域扩张伴淋巴细胞浸润以及胆管周围致密向心性纤维化。
In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct.
请您给我们介绍一下抗肝纤维化药物对于肝星状细胞的可能的作用机制？
Would you please give us a brief introduction on the possible strategies to target HSCs using anti-fibrotic agents?
肝硬化是肝细胞坏死后，肝纤维化和肝细胞再生所致。
Ongoing liver damage with liver cell necrosis followed by fibrosis and hepatocyte regeneration results in cirrhosis.
本综述以肝星状细胞激活与增殖相关信号转导通路为中心，探讨其在肝纤维化发病作用方面的作用机制。
This paper briefly reviews the hepatic stellate cells (HSC) activation and proliferation-related signal transduction pathway and explores the role in the pathogenesis of liver fibrosis.
目的探讨大鼠肝纤维化胶原生成细胞的来源。
Objective To study the sources of the collagen producing cells in rat liver fibrosis.
我们知道肝星状细胞还是纤维化过程中细胞外基质的主要来源。
We know that hepatic stellate cells are still the major source of extracellular matrix during fibrogenesis.
目的研究肝星状细胞(HSC)与肝纤维化和肝硬化的关系。
Objective To investigate the relationship between hepatic fibrosis and hepatic stellate cell (HSC).
目的：为深入探讨肝纤维化的细胞机制，探索经济、稳定的肝星状细胞分离和培养方法。
Objective: To investigate the method of isolation and culture of hepatic stellate cells for studying the cellular mechanisms of hepatic fibrosis.
肝星状细胞的激活、表型改变并分泌大量的细胞外基质是肝纤维化发生的中心环节。
The activation of hepatic stellate cell phenotype change and secretion of extracellular matrix of liver fibrosis is the central link.
结论D MN引起大鼠肝窦内皮细胞损伤及其表型改变可能是其诱导肝纤维化重要的始动机制之一。
Conclusions the damage and phenotypic alteration of the hepatic sinusoidal endothelium may be a vital issue triggering the liver fibrosis induced by DMN.
提示血清HA含量是早期判断肝细胞损伤和肝纤维化程度的有用指标。
The results suggest that immunoassay for HA in serum is a more sensitive index for liver cell damage and hepatic fibrosis.
结论：软肝饮可能通过恢复肝细胞形态及降低炎症细胞因子含量而起到抗肝纤维化的作用。
Conclusion: Ruangan Yin exerts functions of anti-hepatic fibrosis possibly through restoring appearance of cell organs with secreting functions and decreasing contents of inflammatory cytokines.
控制肝星状细胞的激活和增殖并逆肝纤维化的进程是抗肝纤维化研究的重点之一。
The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.
而癌周肝组织无论是肝硬化或肝纤维化均显示正常肝细胞的酶活性。
The surrounding liver tissue either in cirrhosis or in hepatic fibrosis appeared normal hepatic enzymatic activity.
根据肝细胞色素沉积特点及量的变化，可判断血吸虫病小鼠肝纤维化进程以及评判吡喹酮治疗效果。
Therefore, the degree of liver fibrosis in mice with schistosome infection and the effect of praziquantel can be recognized by the level and distribution of pigment.
目的探讨慢性病毒性肝炎患者肝脏B超形态学改变、周围血细胞计数与肝纤维化病理分期之间的关系。
Objective: To discuss the relationships of the hepatic fibrosis stages, liver morphological changes with ultrasonography of type b, and the peripheral blood cell counts in chronic hepatitis.
细胞外基质(ecm)的沉积增加和降解减少是肝纤维化的主要特点。
Increased deposition of extracellular matrix (ECM) and reduced matrix degradation are the major character of liver fibrosis.
结果经图像分析，药物防治组的肝纤维化程度显著降低，细胞凋亡数量显著减少（均P<0.01）。
Results By an image analysis system, the number of hepatocyte apoptosis of the treatment group was more less than that of the control group(P<0.01).
加味复元活血汤能有效地改善肝脏微循环，具有防治实验大鼠肝纤维化，保护肝细胞，恢复肝功能的作用。
MFHD can improve liver microcirculation, protect hepatocytes, recover liver function, lower synthesis and sediment of liver collagen, decompose the collagen.
结论氧化苦参碱在体外具有抑制大鼠贮脂细胞增殖和胶原合成的作用，这对防治肝纤维化可能有一定的临床应用价值。
Conclusion Oxymatrine has the inhibiting potential of rat hepatic stellate cells in vitro, which might be of practical clinical value in prevention and treatment of hepatic fibrosis.
结果：模型组大鼠病理片呈肝纤维化变，贮脂细胞增生活跃，有较大量的IV型胶原沉积。
Result : Hepaticfibrosis appeared, fat-storing cells( FSCs) actively proliferated and the deposit of IV-collagen gradually increased in rat liver.
清肝活血方并可降低肝纤维化标志物、细胞因子水平，抗肝脏脂质过氧化损伤，较明显改善脂肪肝程度。
QGHXR also showed effects in lowering levels of liver fibrosis markers and cytokines, alleviating the anti-lipid superoxidation damage in liver, and could markedly improve the degree of fatty liver.
结论肝脏B超形态学改变、周围血细胞计数对慢性肝炎患者早期肝纤维化的诊断价值是有限的。
Conclusions: the value of diagnosing mild hepatic fibrosis with liver morphological changes with ultrasonography of type b, and the peripheral blood cell counts in chronic liver diseases are limited.
现将肥大细胞、蛋白酶激活受体- 2与肝纤维化的有关进展作一综述。
The following is a review of advances in mast cell, proteinase-activated receptor-2 and liver fibrosis.
骨髓纤维化，骨髓纤维变性在骨髓中成纤维细胞的扩散，常引起贫血症，而且有时也会导致脾和肝的增大。
Proliferation of fibroblastic cells in bone marrow, causing anemia and sometimes enlargement of the spleen and liver.
目的：在精密肝切片中利用乙醛激活肝星状细胞，建立一种星状细胞激活的体外模型，为研究和筛选阻抑肝纤维化发生的药物奠定基础。
AIM: To activate hepatic stellate cells (HSC) in vitro in precision-cut liver slices (PCLS) stimulated by acetaldehyde for studying and screening anti-fibrotic drugs.
最近的实验也表明表面有CCR1和CCR5表达的细胞在促进肝纤维化中也有重要作用。
The latter experiments also identified the cells on which CCR1 and CCR5 expression is important for promoting liver fibrosis.
肝纤维化是各种致病因素导致肝内结缔组织异常增生的肝内弥散性细胞外基质过度沉积的病理过程。
Hepatic fibrosis was caused by intrahepatic connective tissue dysplasia due to many pathological factors, Which was a massive diffuse ECM deposition pathological process in human body.
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