国际肝病：除了肝星状细胞在肝纤维化发生中的重要作用，还有哪些机制参与了肝纤维化的发生？
International Hepatology: Besides the important role of hepatic stellate cell in liver fibrosis development, are there any other important mechanisms involving liver fibrosis development?
国际肝病：目前有肝纤维化治疗的指南吗，对于肝纤维化患者您是如何治疗的？
International Hepatology: Are there any guidelines for liver fibrosis therapy and how do you treat the patients with liver fibrosis in clinical practice?
结论超声积分及超声与血清肝纤维化指标联合应用对肝纤维化无创定量诊断有较高的价值。
Conclusions Ultrasonography quantitative scoring system, especially when it is combined with serum fibrosis markers, has a higher value in noninvasive quantitative diagnosis of hepatic fibrosis.
观察软肝化疒征丸干预肝纤维化的主要作用机制。
The main mechanism of the interfering effects of Ruanganhuazheng Pills (RP) on hepatic fibrosis was studied.
《国际肝病》：几种临床前期的试验研究表明，进行试验的抗肝纤维化药物对于肝纤维化动物模型并不是很有效。
Hepatology Digest: Several preclinical studies showed that experimental anti-fibrotic drugs are not effective in animal models with liver fibrosis.
方法对50例肝纤维化患者和患者住地附近非肝纤维化者作病例对照研究。
Methods By comparing the influential factors in 50 patients with hepatic fibrosis and those without who lived nearby.
目的构建大鼠肝纤维化模型，观察纤维化的病理进程。
Objective To build rat liver fibrosis model and observe its pathological course.
结论慢性肝病临床与纤维化病理分级、分期有良好相关性，有助于肝纤维化的非创伤性诊断。
Conclusion There is good correlation between clinical findings and the pathologic grading and staging, which may aid in the noninvasive diagnosis of liver fibrosis.
目的明确肝纤维化血清学指标对诊断肝纤维化的临床价值。
Objective To evaluate the clinical value of serum fibrosis index in the diagnosis of hepatic fibrosis.
控制肝星状细胞的激活和增殖并逆肝纤维化的进程是抗肝纤维化研究的重点之一。
The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.
目的：建立肝纤维化血清学诊断谱，并探讨其在肝纤维化诊断与疗效考核中的意义。
Objective: to establish a serum diagnostic method for hepatic fibrosis and to explore its value in the diagnosis and curative effect assessment of hepatic fibrosis.
方法：用鸭乙型肝炎病毒（DHBV）阳性血清反复攻击复制鸭乙型肝炎肝纤维化模型，同时用剔毒护肝方治疗，观察其对肝纤维化指标的影响。
Methods: Duck models with hepatic fibrosis were induced by duck hepatitis B Virus (DHBV) and meanwhile treated with Tidu Hugan Decoction. The indexes of hepatic fibrosis were assaged.
为观察慢性乙型肝炎患者的肝脾超声与血清肝纤维化指标的相关性，检查62例慢性乙型肝炎患者肝脾超声、血清肝纤维化指标。
To observe the correlativity between hepatosplenic ultrasonic results and liver fibrosis indexes in patients with hepatitis B, they were detected in 62 subjects.
血清tnf水平与肝组织学检查肝纤维化程度、肝胶原含量及血清肝纤维化指标HA等相关。
The level of serum TNF was correlated with hepatic fibrosis degree by pathological examination hepatic collagen content and HA etc. parameters of hepatic fibrosis.
目的：探讨高脂饮食与酒精对肝纤维化的形成机制，寻求新的肝纤维化动物模型。
Objective: To establish new animal model of hepatic fibrosis with rats and to study the causative mechanism of hepatic fibrosis induced by high fat diet and alcohol.
目的通过大鼠肝纤维化动物模型，研究门冬氨酸鸟氨酸防止肝纤维化的作用。
Objective To study the role of ornithine aspartate on preventing of liver fibrosis through the rat liver fibrotic model.
目的探讨肝炎平对兔血吸虫肝纤维化血清中肝纤维化指标的影响。
Objective To study the antifibrotic effect and possible mechanism of Ganyanping on schistosomal liver fibrosis of rabbits after anthelmintic treatment.
方法采用以人血白蛋白攻击方法制备肝纤维化动物模型，放免法测定血TNF ，免疫组化法观察肝内层粘蛋白改变。
Methods The rat models of hepatic fibrosis were established by human serum albumin(HSA) injection. Serum TNF was detected by RIA method and laminin in the liver was studied by immunohistochemistry.
肝纤维化是各种慢性肝病共有的病理改变，逆转肝纤维化可阻止大多数慢性肝病进展。
Hepatic fibrosis is the common pathological change of chronic liver diseases, and reversal of fibrosis can prevent the progression of most chronic liver diseases.
肝组织中PAI - 1的表达与星状细胞活化有关，可反映肝纤维化的进展，但不能反映肝纤维化程度。
The expression of PAI-1 in liver tissue relates with activity HSCs. It reflects the development of liver fibrosis but not the degree.
结论运用血清学肝纤维化指标评价肝组织纤维化程度时应考虑肝组织炎症程度对肝纤维化指标的影响。
Conclusion the influence of liver inflammation to serum fibrosis markers must be considered when the liver fibrosis staging is evaluated by these markers.
MMP-2、MMP-9免疫组化阳性表达面积，肝纤维化组明显高于对照组（P＜0．05），并随造模时间延长而进行性增加。
The level of MMP - 2 and MMP - 9 was accodingly higher in rats of model group than those of control group (P< 0.05). They increased with the progress of hepatic fibrosis.
结论初步研究结果显示，DWI不能精确区分不同程度的肝纤维化，但可以粗略估计肝纤维化程度。
ConclusionThe preliminary findings show that, DWI can not accurately distinguish different degrees of hepatic fibrosis, but can be a rough estimate of hepatic fibrosis.
在过去的十年中，肝纤维化进展相关的血清标志物研究取得了很大的进展，为肝纤维化的无创诊断带来了新希望。
Thus it is necessary to seek ideal non-invasive method. Last decade's breakthroughs of serum markers brought new hope to the diagnosis.
可能通过受体表达下调降低促纤维化因子作用，进而影响肝纤维化逆转恢复过程。
They might affect the recovery through down-regulating the receptors and decreasing the promotion factors.
结论软肝化坚颗粒可能通过降低C57小鼠肝组织pdgf - B的表达，进而减轻肝纤维化程度和肝组织损伤。
ConclusionRuangan Huajian granule may alleviate the degree of liver inflammation and fibrosis through reducing hepatic expression of PDGF-B in C57 mice with experimental hepatic fibrosis.
本研究对MMP - 2细胞外基质代谢的相关因素进行分析，了解MMP - 2与肝纤维化的关系，如MMP - 2与肝纤维化程度有关，则其可能与预后有关。
In this study, MMP-2 extracellular matrix metabolism-related factors were analyzed to understand the MMP-2 and liver fibrosis, while the MMP-2 and the degree of liver fibrosis, its likely prognosis.
文章对活血化瘀中药在肝纤维化治疗中的作用及机制进行综述，为此类药物在肝纤维化研究和治疗中的应用奠定基础。
The review explains the function and mechanism of the promoting blood circulation for removing blood stasis herbs in treating hepatic...
目的研究肝纤维化的发生机制，寻找新的与肝纤维化相关的生物学标志物。
Objective to study the mechanism of liver fibrogenesis and to find new non-invasive biomarkers.
目的研究肝纤维化的发生机制，寻找新的与肝纤维化相关的生物学标志物。
Objective to study the mechanism of liver fibrogenesis and to find new non-invasive biomarkers.
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