目的：总结和分析间充质干细胞向肝样细胞诱导分化的方法、机制以及存在的问题。
OBJECTIVE: to conclude and analyze the methods, mechanism and existing problems of MSCs differentiation into hepatocyte-like cells.
结果与结论：共收集146篇关于间充质干细胞向肝样细胞诱导分化的文章，纳入31篇符合标准的文献。
RESULTS and CONCLUSION: a total of 146 articles addressing induced differentiation of MSCs into hepatocytes were collected, and 31 articles were included according to inclusion criteria.
结论这一病毒具肝、小肠和淋巴样细胞嗜性，可解释其多途径传播。
Conclusion Transfusion transmitted virus is hepato , spleno , and lymphoid cell tropic, and may has multiple routes of transmission.
在促炎症反应如内毒素、缺血再灌注损伤和免疫反应中，过量释放的细胞因子和前列腺素样物质可引起肝损伤。
During proinflammatory reactions such as endotoxemia, ischemia - reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in liver injury.
结果：16例患者肝组织炎性损害轻微（G1，S0～S1） ，呈现大量毛玻璃样细胞，12例患者肝脂肪变，以大泡性为主。
Results:16 cases had liver mild inflammation(G1, S0~S1), ground glass hepatocytes more commonly. Hepatic steatosis was found in 12 cases and macrovesicular steatosis was the main type.
结论：与动物致癌模型肝中存在卵圆细胞一样，人肝细胞肝癌肝中也存在同样形态和免疫表型特点的卵圆细胞。
Conclusion Oval cells that exhibit the same morphologic and immunophenotypic features as those seen during animal hepatocarcinogenesis are found in human HCC.
目的：了解小鼠胎肝间质干细胞在体外向肌样细胞分化的潜能。
AIM: to study whether mesenchymal stem cells (MSCs) from fetal liver can differentiate into skeletal muscle-like cells.
在肝实质内还可见多个CD34阳性小集落，集落内或周围也可见少许单核样干细胞。
A great many mononuclear stem cells positive for OV6 and CD34 were also found in the hepatic parenchyma.
结论：胎肝中分离出的间质干细胞在体外可以定向诱导分化为肌样细胞。
CONCLUSION: MSCs derived from fetal liver can be induced into skeletal muscle-like cells in vitro.
结论：胎肝中分离出的间质干细胞在体外可以定向诱导分化为肌样细胞。
CONCLUSION: MSCs derived from fetal liver can be induced into skeletal muscle-like cells in vitro.
应用推荐