目的:探讨焦炉工外周血淋巴细胞热应激蛋白70 (HSP70)表达水平及与外周血淋巴细胞遗传损伤之间关系及其意义。
Objective: To investigate the relationship between the expression of heat shock protein70 (HSP70) and genetic damage in coke oven workers and their functions.
不过,还有个悬而未决的问题:假定癌细胞内出现遗传损伤的情况,那么,哪种类型的损伤可以作为肿瘤存在的理想指标?
But it is an open question, given all the genetic damage in a cancer cell, as to which type of damage would be the best marker of a tumor's presence.
DNA修复对遗传信息的准确保存和确保细胞的正常功能是必需的,年龄和DNA损伤的关系一直存在疑问。
DNA repair is essential for the accurate preservation of genetic information and to ensure the healthy functioning of cells, and a connection between aging and DNA damage has long been suspected.
当细胞出现了遗传损伤,如太阳紫外线造成的DNA损害,这被认为是其自毁。
When cells become genetically damaged - such as the DNA damage caused by the sun's ultraviolet rays - they're supposed to self-destruct.
在M_1所产生的叶绿素缺失中,大多数属于体细胞突变,或是由于辐射损伤所致,一般是不能遗传的;
Most of the chlorophyll deletion occurred in M1 were belonged to somatic mutation or caused by radiation injury so that they usually were not inheritable.
近来的研究显示,某些类型遗传损伤是很多肿瘤细胞的共同原因,导致蛋白激酶从细胞内部运动到细胞膜的表面。
Recent research has shown that certain types of genetic damage, common to many cancer cells, lead to the movement of PKB from the interior of the cell to its surface membrane.
前言: 目的:观察中草药益母草对硫酸镉引起的小鼠骨髓细胞遗传物质损伤的防护作用。
Objective:To observe the preventive effect of Herba leonuri on genetic damage induced by CdSO 4 in the bone marrow cells of mice.
结论:迁延照射造成的细胞遗传学损伤较一次照射严重,且修复缓慢。
CONCLUTION: There were more severe cytogenetic damage and slower repair in continual exposure to radiation than in a single irradiation.
目的比较外周血淋巴细胞和口腔脱落细胞彗星试验在丙烯腈作业人群遗传损伤评价中的效果。
Objective To compare the effect of Comet assay in peripheral blood lymphocytes and buccal mucosal cells on detecting genetic damage in workers exposed to acrylonitrile (ACN).
目的用碱性单细胞凝胶电泳技术检测苯作业工人外周血淋巴细胞DNA损伤,研究苯的遗传毒性。
Objective To detect DNA damage in peripheral lymphocytes of workers exposed to benzene by alkaline single cell gel electrophoresis and to study the genetic toxicity of benzene.
表明该场所的上述多综同时存在的危害物可对职业接触者的免疫功能有抑制作用,并可能使染色体细胞遗传物质损伤修复能力降低。
Indicate the place of the simultaneous presence of hazards in the occupation exposure of immune function inhibition, and may cause cell damage of genetic materials in lower repair capability.
结果表明,各水样的有机浓集物均可对人外周血淋巴细胞DNA产生不同程度的损伤,存在一定的遗传毒性。
The results showed that DNA damages in human peripheral blood lymphocytes were induced after exposure to the organic extracts from all water samples and the genetic hazard also existed.
此外,还探讨了泥鳅红细胞的微核来源和利用泥鳅红细胞核的遗传损伤监测河水水质的可行性及注意问题。
In addition, it also studied the sources of the erythrocytes in loach, the possibility to monitor the river water quality and the problems that must to be noticed.
结论:二氯乙酸是肝细胞的DNA损伤剂,致癌作用可能与其dna损伤作用有关,属于遗传致癌物。
Conclusion: DCA is an agent of DNA damage to hepatocyte, and belongs to genetic carcinogen. Its carcinogenesis may be related with its action of inducing DNA damage.
单细胞凝胶电泳被广泛应用于遗传毒理学、DNA损伤与修复的检测、环境污染检测、细胞凋亡机制的研究等诸多领域。
Single cell gel electrophoresis is applied for genetic toxicology, DNA damage and detection, environmental pollution detection, apoptosis mechanism research et al.
该结果提示苯妥英钠对细胞核遗传物质具有一定损伤作用。
It suggests phenytoin sodium has some injury to caryon genetic material.
利用蚕豆根尖微核技术研究农药乙蒜素和细菌溴腈对蚕豆根尖细胞的遗传损伤,测定蚕豆根尖细胞的微核率、有丝分裂指数和染色体畸变率。
With different concentrations of sewage and aluminum sulfate as a mutagen, pea root tip cells in the mitotic index, micro-rate and the rate of chromosomal aberrations are determined.
单细胞凝胶电泳或彗星试验是在暴露人群中评价遗传学损伤的新式方法。
The single cell gel electrophoresis is a new technique to evaluate the genetic damage in exposed populations.
从实验结果可以看出,低剂量的使用并不会造成明显的细胞损伤及遗传毒性。
From the experimental results can be seen that the use of low dose does not cause obvious cell injury and genotoxicity.
结论对丙烯腈接触人群进行遗传损伤监护时,外周血淋巴细胞彗星试验比口腔脱落细胞彗星试验更灵敏。
Conclusions When assessing the early genetic damage of ACN exposed population during health surveillance, Comet assay in peripheral lymphocytes was more sensitive than that in buccal mucosal cells.
提示长期饮用污染井水农民的细胞遗传物质已受到一定程度的损伤。
It is suggested that the cytogenetic materials of those peasants who have drunk t...
提示长期饮用污染井水农民的细胞遗传物质已受到一定程度的损伤。
It is suggested that the cytogenetic materials of those peasants who have drunk t...
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