肝细胞转录因子3蛋白(HNF3)在调节新陈代谢及肝脏、胰脏等代谢组织的分化过程中起着关键作用。
Hepatocyte nuclear factor 3 (HNF3) proteins play pivotal roles in the regulation of metabolism and the differentiation of the metabolic tissues such as pancreas and liver.
成骨细胞分化所需的第二个重要转录因子是一种具有锌指结构的，对骨形成十分重要的转录因子。
A second important transcription factor required for osteoblastic differentiation is osterix.
后来，来自美国哈佛大学的科学家证明，通过使老鼠的胰腺细胞感染上只携带三个转录因子的基因病毒，能将其重组。
Later, scientists from Harvard University in the us showed that mouse pancreas cells could be reprogrammed by infecting them with viruses carrying genes for just three transcription factors.
例如，电路可以模拟出乳糖代谢基因与调节细菌细胞内乳糖代谢基因表达的转录因子之间的互动过程。
For example, circuits can simulate the interactions between genes involved in lactose metabolism and the transcription factors that regulate their expression in bacterial cells.
他们认为每类细胞都应该有一组特殊的转录因子。
Each type of cell is thought to have a special set of transcription factors.
Yamanaka和Yu博士制造干细胞的方法有一点受到质疑：那就是他们用来说服细胞产生合适的转录因子的方式。
The main thing to be said against the methods used by Dr Yamanaka and Dr Yu is the way that they persuade their experimental cells to churn out the appropriate transcription factors.
这一新研究领域依赖于获得被称作转录因子的主蛋白质，这种蛋白质控制细胞中哪组基因被激活，从而也就控制了细胞拥有哪些特性。
The new field depends on capturing master proteins called transcription factors that control which sets of genes are active in a cell and thus what properties the cell will possess.
如果试验能成功，新的方法将取代已有“应急的”方法，通过用转录因子获得带有特定个体基因组的多能干细胞。
If that can be done, the new method may take over from the existing lash-up by which pluripotent stem cells with the genomes of particular individuals are made using transcription factors.
这些基因的转录因子，它控制表达的许多基因，基因与细胞迁移和呼吸道过敏性疾病。
These genes were transcription factors, which control the expression of many genes, and genes associated with cellular migration and allergic airway disease.
Yamanaka通过对老鼠进行实验发现有一组转录因子可以改变基因的表达方式，让这些基因说：“我就是胚胎干细胞”。
What Dr Yamanaka discovered in his work on mice was a group of transcription factors that switched on the pattern of gene expression which says, “I am an embryonic stem cell.”
转录辅激活蛋白和其他细胞因子及结构共同作用控制基因活动。
Transcriptional coactivators work with other cellular factors and machinery to control the activity of other genes.
转录因子的活动方式与细胞的‘设置’有点相似，联想一下手机或电脑的‘设置’就明白了。
Transcription factors act a little bit like the 'Settings' of our cells, just like the Settings on our phones or computers.
2007年，研究人员宣布，通过让人类皮肤细胞接触影响DNA的蛋白质转录因子而生成iPS细胞。
In 2007, researchers announced the creation of iPS cells from human skin cells by exposing them to proteins called transcription factors that influence DNA.
这就引出问题，转录因子是否能直接诱导其它明确的体细胞，而不仅是未分化状态的细胞。
This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state.
目的：头叉转录因子箱（FOXP3）---调控大量基因的表达而且有报道说已在肿瘤细胞中有表达。
Purpose: The transcription factor forkhead box P3 (FOXP3) up- or down regulates a large number of genes and has been recently reported to be expressed in tumor cells.
最近的研究表明小鼠和人成纤维细胞在四种转录因子的联合下可重新转变为多向潜能状态。
Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors.
结果表明，人工转录因子能有效地促进外源基因在哺乳动物细胞中的表达。
These results indicated that artificial transcription factor is potent in the enhancement of exogenous gene expression in mammalian cells.
EYA蛋白作为重要的转录调控因子，直接参与胚胎发育过程中的细胞增殖、组织分化和器官发育。
EYA was thought to function as a transcriptional regulatory factor that plays an important role in cell proliferation, tissue differentiation and embryonic development.
已报道的包括转录因子、信号通路受体、黏附因子在内的ES细胞特异性标志与ES细胞的自我更新和全能性具有密切关系。
Es cell markers reported previously including transcription factors, receptors, adhesion molecules and so on, are involved in the mechanism of self-renew and differentiation initiation of es cells.
目的克隆激活转录因子(atf)5，构建其真核表达载体，观察其在细胞中的表达定位。
Objective to clone the gene activating transcription factor 5 (ATF5), construct the expression plasmid and detect the localization of ATF5 in cultivated cells.
转录最高的基因与功能相关，如细胞粘附，基质蛋白，生长因子，受体和蛋白酶。
The most highly transcribed genes relate to functional groupings such as cell adhesion, matrix proteins, growth factors and receptors, and proteases.
LMO2是细胞中介导转录因子复合物形成的重要接头分子。
LMO2 is an important molecule mediating the formation of transcription factor complex in normal hematopoietic cells.
PPAR激动剂，是细胞核激素受体家族转录因子的一个成员，被广泛用来治疗II型糖尿病，而且相对无毒。
Agonists of PPAR, a member of the nuclear hormone receptor family of transcription factors, are widely used in the treatment of type II diabetes and are relatively non-toxic.
我们假设，联合表达神经系特异性转录因子可以直接将成纤维细胞转换成神经元细胞。
We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons.
结果提示，在输卵管细胞中存在细胞特异性转录因子。
It is suggested that there are some of cell specific transcription factors in the primary cultured chicken oviduct cells.
目的探讨甲状腺转录因子1 (TTF 1)在浆膜腔积液肺腺癌细胞中的表达，为肺腺癌的诊断和鉴别诊断提供新的依据。
Purpose to analyze the expression of thyroid transcription factor-1 (TTF-1) in the metastatic pulmonary adenocarcinoma cells in serous effusions.
生物学中的一个基础问题就是细胞如何根据不同的刺激，利用转录因子来协调成千上万个基因的表达。
A fundamental question in biology is how the cell USES transcription factors (TFs) to coordinate the expression of thousands of genes in response to various stimuli.
他解释说，当科学家提取干细胞并将其转化为特化细胞时，所做的就是改变某些转录因子的水平。
When scientists take stem cells and turn them into specialized cells, they do so by changing the levels of a few transcription factors, he explained.
近年来，转录因子逐渐成为分子遗传学和细胞分子生物学研究领域的重要内容。
In recent years, studies on transcription factors have been paying a great deal of attention in the fields of plant molecular biology and molecular genetics.
本研究表明，干扰素可以通过抑制肿瘤依赖性转录因子的表达来达到抑制肿瘤的作用，这种转录因子可以调控肿瘤细胞的生长。
The present study indicates that interferon can suppress cancer growth by inhibiting expression of a cancer-dependent transcription factor that controls genes that regulate cancer cell growth.
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