这门课程是介绍以应用于组织工程学中设计医疗植体、人工器官和基质为主的材料科学和细胞生物学。
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering.
研究表明，移植物中的胶原蛋白部分与材料基质中的成纤维细胞和成骨细胞的结合密切相关。
The portion of collagen protein incorporated in the graft is thought to be responsible for binding fibroblasts and osteoblasts in the material matrix.
细胞实验显示骨髓基质细胞在这种多孔材料的表面和孔隙中生长良好。
Cell test showed that bone marrow stromal cells can growth on the surface and in the porosity of this kind of glass-ceramic.
目的：利用软骨微粒脱细胞基质这种新型支架材料及纤维蛋白胶，体外构建可塑形及具有良好生物相容性的组织工程化软骨。
AIM: To establish engineered cartilage with good biocompatibility and plasticity in vitro with fibrin glue and a new material of stent made by cartilage microparticle acellular tissue matrix (CMACTM).
本文综述近年来组织工程心脏瓣膜研究进展情况，并从基质材料、种植细胞及动物实验各方面探讨构建组织工程心脏瓣膜的必要性、可行性及前景。
This article reviews the current state of tissue engineering heart valve and discusses its necessity, feasibility and prospects about implanting materials, seeded cells and animal experiments.
目的：应用纤维蛋白胶作为细胞支架进行兔骨髓基质细胞立体培养，探讨其作为新型骨组织工程支架材料的可行性。
AIM: to observe three-dimensional culture of rabbit marrow stromal cells (MSCs) in fibrin glue in vitro, and discuss the feasibility of the fibrin glue to be use as a kind of scaffold material.
因此，寻找能充分发挥组织再生潜力的细胞外基质材料是研究的核心内容。
Therefore, it was the core research to find the extracellular matrix materials that have developed tissue regeneration potential.
目的：制备人关节软骨脱细胞基质，为进一步研究关节软骨基质作为细胞外支架材料提供方法学资料。
OBJECTIVE:To prepare human articular cartilage acellular matrix so as to provide a methodological basis for further study of articular cartilage acellular matrix as cell scaffold materials.
结论人脱细胞骨复合经诱导的骨髓基质细胞在体外具有有效的成骨功能，是一种较为理想的骨组织工程材料。
Conclusion HAB loaded with induced BMSCs has an excellent osteogenic function in vitro and presents an effective potential to be a good bone tissue engineering material.
制备领下腺脱细胞基质支架材料的浸提液，通过急性全身毒性试验，分析脱细胞后的生物衍生支架材料对机体的毒性作用。
The extracting liquid of submandibular gland acellular matrix scaffold material was made, and its toxicity effect to the body was analyzed by acute systemic toxicity test.
结论：人脱细胞骨复合经诱导的骨髓基质细胞在体外具有有效的成骨功能，是一种较为理想的骨组织工程材料。
CONCLUSION: HAB loaded with induced BMSCs has an excellent osteogenic function in vitro and shows an effective potential as a good bone tissue engineering material.
本实验进行脱细胞骨基质制备，去除细胞成分，并进行形态学观察，为骨组织工程的新型天然支架材料提供依据。
This experiment prepares ACEM by removing cell components and carries morphologic study to provide foundation for new natural supporting material of bone tissue engineering.
这些脂肪组织来源的基质细胞有望在不久的将来取代骨髓细胞成为再生细胞治疗的重要材料。
ADSC might be an important material for regenerative cell therapy in the near future, replacing bone marrow cells.
天然胶原类组织，经过脱细胞处理后，降低免疫原性，可作为组织工程的支架材料，本文就脱细胞的方法以及无细胞胶原基质的研究进展作一综述。
As scaffold, nature collagen must be decellularized to decrease its immunity. The methods of decellularization and the progress of study on acellular collagen matrix are reviewed in this article.
简要介绍了丝素蛋白应用于手术缝合线、隐形眼镜、人工血管、创面覆盖物、硬脑膜修补材料、细胞培养基质方面的研究进展。
The research progress of silk fibroin in suture, contact lenses, manual vein, wound-dressing, dural substitute, cell culture matrix is summarized in this paper.
从细胞组织学、细胞增殖两方面研究天然高分子材料—无细胞猪真皮基质(APDM)对成纤维细胞和内皮细胞的影响作用。
Fibroblasts and endothelial cells were cultured on the surface of acellular porcine dermal matrix (APDM), and cell histology, cell proliferation were studied.
本文综述了生物材料作为细胞外基质，对细胞粘附、细胞生长及细胞凋亡的影响。
This article reviewed the effect of biomaterial as ECMs on the adhesion, proliferation and apoptosis of cells.
结论：骨髓基质细胞-藻酸钙-生长因子复合材料能形成软骨及骨组织。
CONCLUSION: The compound composed of calcium alginate, BMSCs and growth factor might form bone and cartilaginous tissue.
并在这基础上，把骨髓基质干细胞与生物支架材料复合培养，在体外构建工程软骨和软骨下骨修复体。
Then, on this basis, the bone marrow stromal cells were cultured with the scaffold biomaterials, and the engineering cartilage and subchondral bone restorations were constructed in vitro.
经固定化颗粒传质试验与固定化细胞耐毒性试验，说明聚乙烯醇是一种对基质传质效果好，且能保护细胞活性免受水中毒性物质毒害的良好的包埋固定化材料。
Experiment results showed that, PVA is a good kind of entrapping agent in the diffusion and it can protect the activity of microbial cell from the toxic.
目的探讨脱细胞基质、胶原蛋白基质网架、胶原凝胶的不同支架材料上构建人工真皮的可行性。
Objective To build artificial dermis by using the acellular dermis matrix (ADM), collagen membrane and collagen gel as scaffolds.
结论：无细胞真皮基质是比较理想的软组织填充材料。
Conclusion: Acellular dermal matrix is a ideal graft material for soft tissue augmentation.
天然生物衍生材料主要包括胶原、氨基匍聚糖、纤维蛋白凝胶、透明质酸、几丁质及脱细胞处理后的天然细胞外基质等。
The natural biological organism derived materials included mainly collagen, fibrin gelatum, hyaluronic acid, chitin and natural extracellular matrix after acellular disposal, etc.
就骨髓基质干细胞分离、诱导分化为软骨细胞的方法、载体材料及目前存在的问题加以综述。
In this article, isolation and differentiate regular of BMSCs, method of BMSCs induced to chondrocytes, scaffold of cartilage tissue engineering and problems of current existent were reviewed.
将腺病毒感染的骨髓基质干细胞接种于修剪成一定形状的PLGA上，经电镜观察可见细胞贴附于材料表面和孔隙内并增殖。
Adenovirus-infected MSCs seeded onto PLGA showed high level of proliferation, and mass synthesis of cell matrix was observed with electronic microscoping.
观察细胞在生物材料上附着、生长、增殖及细胞分泌细胞外基质情况。
The adhesion, growth, proliferation of BMSCs on the materials, as well as extracellular matrix secretion were observed.
采用酶动力法测成骨细胞在基质材料上培养2，4，6 天后的碱性磷酸酶（ALP）活性。
Alkaline phosphatase (ALP) activity of osteoblasts was determined by enzyme dynamical method at 2d, 4d and 6d .
在探索生物材料过程中，我们鉴定出具有多种生物化学和生物学功能的羊贲门窦基质(OFM)，一种大而厚的细胞外基质。
In the search for biomaterials we have identified ovine forestomach matrix (OFM), a thick, large format ECM which is biochemically diverse and biologically functional.
目的：探索一种简单的制备壳多糖细胞外基质网架的方法，考察该基质网架作为组织工程支架材料应用的可行性。
Objective to explore one simple way of preparation of chitosan extracellular matrix wire frame, and investigate its application as scaffold for tissue engineering.
将制成的多孔泡沫材料与骨髓基质细胞复合，进行兔关节软骨修复实验，结果表明动物试验效果良好。
The foams were combined with the cells to test the repairing of the cartilage of rabbit. The result was good.
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