结论FTY720在体外可呈时间依赖诱导正常大鼠gmc凋亡，其机制与影响细胞周期调节蛋白及凋亡相关基因的表达有关。
Conclusion FTY720 can induce GMC apoptosis in a time-dependent manner, probably through influencing gene expression of cell cycle regulatory proteins.
正由于凋亡相关蛋白和细胞周期调节因子间的相互作用，使恶性肿瘤保持较高的细胞累积率。
It is because the reciprocal activation of apoptotic proteins and cell cycle control factors that maintain a higher cell accumulation rate in malignant tumors.
研究发现蛋白磷酸化参与细胞死亡途径的调节，影响亚细胞定位、细胞保护、细胞周期进程。
Protein phosphorylated participates in regulation of cell death pathway, location, cell protection, and transition of cell period.
AT M激酶调节许多蛋白，涉及细胞周期检验点的控制、细胞凋亡和DNA修复。
ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair.
极光激酶A（AIK）是一种调节细胞周期的丝氨酸/苏氨酸蛋白激酶，在多种肿瘤细胞系中过表达（1-3）。
Aurora A (AIK) is a cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines (1-3).
在细胞周期中，PIAS蛋白是细胞衰老和细胞凋亡的调节子，可促进细胞的扩散和衰老。
In mitotic cycle, PIAS adjusts cell senescence and cell perish, which can promote cell proliferation and senile.
经磷酸化活化的丝裂原活化蛋白激酶，可参与多种细胞生命活动，如调节基因转录，诱导细胞凋亡、调节细胞周期等。
The MAPK which activated through phosphorylation involve several cell life activities, just like the control gene transcription, induce cell death, regulate cell circle and so on.
结论：DCN可能为一种负性调控蛋白，可通过调节细胞周期，抑制肝癌细胞的增殖，促进其凋亡。
CONCLUSION: DCN may be a negative regulatory protein inhibiting hepatoma carcinoma cell proliferation through inhibiting cell cycle and inducing apoptosis of cell in vitro.
细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。
Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
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