目的探讨细胞周期调节因子在肺结核合并肺癌中的作用。
Objective to explore the role of cell cycle regulators in tuberculosis with lung carcinoma.
目的：肿瘤的本质是细胞周期调节失控，细胞呈自主的、无限制的增殖。
Objective the essential attribute of tumor is the loss of control in the cell cycle regulation, and the cells proliferate unlimitedly.
正由于凋亡相关蛋白和细胞周期调节因子间的相互作用，使恶性肿瘤保持较高的细胞累积率。
It is because the reciprocal activation of apoptotic proteins and cell cycle control factors that maintain a higher cell accumulation rate in malignant tumors.
最初，基因芯片被用于某些与基因表达有关的生物过程的研究，如细胞周期调节或疾病的分类，如癌症。
Originally, microarrays were used to study processes such as cell cycle regulation, or to profile diseases such as cancer; areas of research that studied gene expression as a matter of course.
泛素酶usp17在肿瘤活检标本中高表达，受细胞周期调节，且是细胞由G 1期进入S期的必需者。
The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。
Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
这些基因分别与细胞增殖、基因转录、凋亡、信号转导、DNA损伤修复、肿瘤分化和浸润转移及细胞周期调节等相关。
These genes were involved in cell proliferation, gene transcription, apoptosis, signal transduction, DNA damage and repair, tumor differentiation and metastasis, cell cycle, and so on.
结论FTY720在体外可呈时间依赖诱导正常大鼠gmc凋亡，其机制与影响细胞周期调节蛋白及凋亡相关基因的表达有关。
Conclusion FTY720 can induce GMC apoptosis in a time-dependent manner, probably through influencing gene expression of cell cycle regulatory proteins.
干扰素调节因子- 1 (IRF - 1)参与炎症、细胞周期和细胞凋亡等的分子机制。
Interferon regulatory factor-1 (IRF-1) is involved in the molecular mechanisms of inflammation, cell cycle, and apoptosis.
在细胞周期中，异染色质会被进行动态的调节，以响应发育信号。
Heterochromatin is dynamically regulated during the cell cycle and in response to developmental signals.
大肠癌的发生同其它肿瘤一样是细胞周期的调节失控导致细胞的增殖和分化异常所致。
PurposeLike other tumors, the occurrence of colon cancer is induced by the deregulation of cell cycle resulting in the abnormal proliferation and differentiation of cells.
JRA的发生可能与DC细胞周期、凋亡的调节以及DC介导的免疫放大机制有关。
JRA mechanism may be related to immunological regulation of DC cell cycle and apoptosis, as well as immunological amplification mechanism mediated by DC.
研究发现蛋白磷酸化参与细胞死亡途径的调节，影响亚细胞定位、细胞保护、细胞周期进程。
Protein phosphorylated participates in regulation of cell death pathway, location, cell protection, and transition of cell period.
细胞周期调控是细胞增殖调节的核心环节，与细胞癌变关系十分密切。
Cell cycle regulation is the core event of cell proliferation regulation, which has a close relationship with cell carcinogenesis.
中心体作为细胞的主要微管组织中心，在细胞周期过程中建立两极纺锤体，调节细胞有丝分裂，从而对维持染色体的稳定起着重要的作用。
The centrosome, the major microtubule organizing center regulates cell division through forming bipolar mitotic spindles and plays an essential role in the maintenance of chromosomal stability.
在细胞周期中，PIAS蛋白是细胞衰老和细胞凋亡的调节子，可促进细胞的扩散和衰老。
In mitotic cycle, PIAS adjusts cell senescence and cell perish, which can promote cell proliferation and senile.
经磷酸化活化的丝裂原活化蛋白激酶，可参与多种细胞生命活动，如调节基因转录，诱导细胞凋亡、调节细胞周期等。
The MAPK which activated through phosphorylation involve several cell life activities, just like the control gene transcription, induce cell death, regulate cell circle and so on.
TSH对细胞增殖及分化的作用与细胞周期相关，可通过同一信号分子调节细胞生长，是细胞增值与分化的关键因素。
Conclusions As a growth stimulating factor, TSH can modulate cultured thyroid cell proliferation and differentiation through the same signal molecule.
结论：小檗碱对PG细胞增殖具有抑制作用，后者可能与调节细胞内活性氧自由基产生从而影响细胞周期进程有关。
CONCLUSION: Berberine has an inhibitory effect on the proliferation of PG cells, and these effect may be carried out by regulating the production of intracellular ROS and the process of cell cycle.
AT M激酶调节许多蛋白，涉及细胞周期检验点的控制、细胞凋亡和DNA修复。
ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair.
本发明公开了一种磷酸激酶RIOK2或其激动剂或拮抗剂的用途，用于制备调节细胞周期的调节剂。
The invention discloses an application of phosphokinase RIOK2 or relative activator or antagonist, used to prepare the adjuster for adjusting cell period.
本文主要就CAK自身活性调节及其对细胞周期的调控进展作一综述。
This review focuses on the regulation of CAK activity via its three subunits and its regulation on the cell cycle progression.
极光激酶A（AIK）是一种调节细胞周期的丝氨酸/苏氨酸蛋白激酶，在多种肿瘤细胞系中过表达（1-3）。
Aurora A (AIK) is a cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines (1-3).
Chk1发挥其细胞周期检验点调节机制部分经由调控磷酸酶家族的cdc25。
Chk1 exerts its checkpoint mechanism on the cell cycle, in part, by regulating the cdc25 family of phosphatases.
周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.
结论：DCN可能为一种负性调控蛋白，可通过调节细胞周期，抑制肝癌细胞的增殖，促进其凋亡。
CONCLUSION: DCN may be a negative regulatory protein inhibiting hepatoma carcinoma cell proliferation through inhibiting cell cycle and inducing apoptosis of cell in vitro.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
应用推荐