目的：探讨苯那普利对糖尿病大鼠肾组织细胞周期蛋白激酶抑制剂p 21 CIP1蛋白表达的影响。
To investigate the effect of benazepril on expression of cyclin kinase inhibitor P21 CIP1 protein in renal tissue of diabetic rats.
细胞周期调控机制的核心是一组蛋白激酶。
The core of cell cycle regulation and control mechanism are relative to a group of protein kinase.
p53的激活能够引起细胞周期捕获和DNA修复或细胞凋亡(1)。离体或者在体情况下，p 53可以在多个位点被几个蛋白激酶进行磷酸化(2,3)。
Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2, 3).
极光激酶A（AIK）是一种调节细胞周期的丝氨酸/苏氨酸蛋白激酶，在多种肿瘤细胞系中过表达（1-3）。
Aurora A (AIK) is a cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines (1-3).
经磷酸化活化的丝裂原活化蛋白激酶，可参与多种细胞生命活动，如调节基因转录，诱导细胞凋亡、调节细胞周期等。
The MAPK which activated through phosphorylation involve several cell life activities, just like the control gene transcription, induce cell death, regulate cell circle and so on.
主要观察指标：神经细丝的磷酸化程度及糖原合酶激酶3、细胞周期依赖性蛋白激酶5的酶活性。
MAIN OUTCOME MEASURES: The degree of NF phosphorylation and the activities of GSK-3 and CDK-5 were mainly observed.
主要观察指标：神经细丝的磷酸化程度及糖原合酶激酶3、细胞周期依赖性蛋白激酶5的酶活性。
MAIN OUTCOME MEASURES: The degree of NF phosphorylation and the activities of GSK-3 and CDK-5 were mainly observed.
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