在肿瘤药物治疗中，首次把目标放在调节导致疾病的细胞信号通路。
It was first in oncology that therapy was aimed at the deregulated cell signaling that leads to the disease.
然而，许多人类疾病(包括癌症)的细胞信号通路发生错误。
However, in a number of human diseases, including cancer, cell signaling pathways can go awry.
上述两种抑制剂均能调节与多种细胞功能和细胞信号通路网路相关的蛋白质的表达。
Both of them can induce a potent alteration of the proteins involved in many cell functions and signal pathways.
目前认为垂体腺瘤的发生与基因突变、生长因子、细胞受体、转录因子和细胞信号通路等有关。
The pathogenesis of pituitary adenomas is considered to be related with gene mutation, growth factors, cell receptors, transcription factors, and cellular signaling pathways.
这些改变被定义为一组12个核心的细胞信号通路和过程，每个通路在肿瘤有67%到100%的改变。
These alterations defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67% to 100% of the tumors.
结论：针刺能刺激大鼠胃黏膜细胞信号转导通路中蛋白激酶c的活化，并且存在经脉-脏腑的特异性联系。
CONCLUSION: the acupuncture can stimulate the activation of PKC in gastric mucous cell signal conductive pathway of rats, and there is a special correlation between meridian and internal organs.
随着对肿瘤发生机制研究的深入，作用于细胞信号转导通路的药物开始引起研究者的关注，成为抗肿瘤药物研发的重要靶点之一。
With the thorough research of tumor mechanism, drugs acting on cell signal transduction pathway began to attract attention of researchers as an important target for anticancer drug development.
文章从细胞信号传导通路、细胞生存途径、基因治疗及血管生成四方面简要介绍这些新靶点和已经或正在研发的新药物。
This review briefly focused on the new targets and agents from the following four aspects: signal transduction pathway, cell survival pathway, gene therapy, and angiogenesis.
癌基因和抑癌基因的发现，细胞信号传导通路的阐明，极大地丰富了人们对细胞癌变机制的认识。
The discovery of oncogenes and tumor suppressor genes, and the research of signal transduction pathway yield profound insights into the mechanisms of carcinogenesis.
研究人员评估了三种不同的信号通路，这些通路参与了控制细胞信号传导以及管理细胞活动的复杂传导系统。
The researchers evaluated three different pathways involved in cell signaling, the complex system of communication that governs cell actions.
促分裂原活化蛋白激酶（MAPK）级联途径信号通路在真核生物细胞信号的转换和放大过程中起重要作用。
The mitogen-activated protein kinase (MAPK) cascade plays an important role in signal conversion and amplification of extracellular stimuli in eukaryotic organisms.
本研究室的主要研究方向为心肌肥大时的细胞信号转导通路及脂联素对心脏功能的影响。
The main interest of the laboratory is focused on the signal transduction pathway during cardiac hypertrophy and the effect of adiponectin on cardiac function.
结论：大鼠尾加压素II是大鼠肺主动脉有效的血管收缩剂，细胞信号转导通路MAPK的激活参与其收缩效应。
CONCLUSION: rat U-II was a potent vasoconstrictor of rat main pulmonary arteries and this response was mediated through MAPK.
结论：大鼠尾加压素II是大鼠肺主动脉有效的血管收缩剂，细胞信号转导通路MAPK的激活参与其收缩效应。
CONCLUSION: rat U-II was a potent vasoconstrictor of rat main pulmonary arteries and this response was mediated through MAPK.
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