今后，我们将在表观遗传层面对TFPI-2基因的修饰和相关组蛋白的修饰进行深入研究。
We will further investigate the relationship of histone modification and promoter methylation on the expression of TFPI-2.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
当甲基加到组蛋白后，这些基团会修饰它的性质并改变它上面特定基因的表达频率。
When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
在染色体中，SATB1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态。
SATB1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.
表观遗传标记，例如组蛋白修饰，对于机体细胞的分化也很重要。
Epigenetic marks, such as the modifications of the histones, are also important for the specialisation of the body's cells.
这里，我们报告了来自于人类CD 4细胞中39个组蛋白修饰的分析的模式。
Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4 t cells.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
在组蛋白上发生的共价修饰组合，具有功能意义，能被蛋白质识别。
Combinations of covalent modifications on histones that have a functional significance and are recognized by proteins.
我们将在分析组蛋白修饰和DNA甲基化数据的背景下，讨论解决这些挑战的方法。
We will discuss methods to address these challenges in the context of analyzing histone modifications and DNA methylation data.
总结了组蛋白精氨酸甲基化修饰体系的最新研究进展。
Here, the most recent progresses in the methylation studies of histone arginine were summa.
组蛋白尾端不同的化学修饰往往和基因的表达调控有着密切的关系，乙酰化就是常见的一种修饰形式。
Gene expression is often closely related to the different chemical modification ends of protein, acetylation is a kind of common form of modification.
组蛋白是染色质的核心，其尾部的共价修饰组成组蛋白密码，调节许多生物学事件。
Histone is the nucleus of chromatin, the covalent modifications in its tails form the histone codes that regulate a number of biological processes.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。
This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may contribute to the development of alimentary canal neoplasms.
结合以上去乙酞化酶抑制剂的实验结果，我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。
Combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
组蛋白乙酰化修饰与基因的表达调控相关，参与了各种肺部疾病的病变过程。
The acetylation of histone is related to gene expression and regulation, which takes part in the pathological courses of all kinds of lung diseases.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
在植物和动物中，基因表达能够通过非dna自身，而是通过与DNA相互作用的DNA或组蛋白的化学修饰的变化来改变基因表达。
In plants and animals, gene expression can be altered by changes not to DNA itself but rather chemical modifications either to DNA or to histones that interact with DNA.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
这些修饰为改变染色质结构和易接近性服务，并作为转录因子或其他组蛋白修饰酶的停靠位点。
These modifications serve to alter chromatin structure and accessibility, and to act as docking sites for transcription factors or other histone modifying enzymes.
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP与CTCF）的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
组蛋白的特点是大量的翻译后修饰，这些修饰可以影响基因转录。
Histones are characterized by numerous posttranslational modifications that influence gene transcription.
Luger和他的同事随即包装了从Shokat小组得来的修饰过的组蛋白，形成核小体和染色质的重组体。
Luger and her colleagues next packaged the modified histones they received from Shokat's group into recombinant nucleosomes and chromatin.
我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
We demonstrated a direct role for histone modifications in alternative splicing.
我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
We demonstrated a direct role for histone modifications in alternative splicing.
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