染色体带型和组蛋白修饰的特有模式相关。
Chromosome banding patterns are correlated with unique patterns of histone modifications.
最近的研究对应的组蛋白修饰在酵母基因组中。
Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome.
我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
We demonstrated a direct role for histone modifications in alternative splicing.
表观遗传标记，例如组蛋白修饰，对于机体细胞的分化也很重要。
Epigenetic marks, such as the modifications of the histones, are also important for the specialisation of the body's cells.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
这里，我们报告了来自于人类CD 4细胞中39个组蛋白修饰的分析的模式。
Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4 t cells.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
我们将在分析组蛋白修饰和DNA甲基化数据的背景下，讨论解决这些挑战的方法。
We will discuss methods to address these challenges in the context of analyzing histone modifications and DNA methylation data.
在染色体中，SATB1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态。
SATB1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.
这些修饰为改变染色质结构和易接近性服务，并作为转录因子或其他组蛋白修饰酶的停靠位点。
These modifications serve to alter chromatin structure and accessibility, and to act as docking sites for transcription factors or other histone modifying enzymes.
在这种方法中，组蛋白修饰具有影响很多基本生物学过程的潜力，它们中的一些可能是表观上遗传的。
In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
我们在一组人类基因中发现了与剪接结果相关的独特的组蛋白修饰特征，及组蛋白导致剪接位点转换的调节。
We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching.
表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
最近许多实验室包括我自己的实验室对组蛋白修饰进行研究，这些研究显示组蛋白h3在对葡萄糖的反应中非常重要。
More recently a number of laboratories including my own have studied histone modifications and these studies now show that histone H3 is thought to be critical in the response to glucose.
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP与CTCF）的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。
This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may contribute to the development of alimentary canal neoplasms.
当甲基加到组蛋白后，这些基团会修饰它的性质并改变它上面特定基因的表达频率。
When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
在组蛋白上发生的共价修饰组合，具有功能意义，能被蛋白质识别。
Combinations of covalent modifications on histones that have a functional significance and are recognized by proteins.
组蛋白尾端不同的化学修饰往往和基因的表达调控有着密切的关系，乙酰化就是常见的一种修饰形式。
Gene expression is often closely related to the different chemical modification ends of protein, acetylation is a kind of common form of modification.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
组蛋白是染色质的核心，其尾部的共价修饰组成组蛋白密码，调节许多生物学事件。
Histone is the nucleus of chromatin, the covalent modifications in its tails form the histone codes that regulate a number of biological processes.
总结了组蛋白精氨酸甲基化修饰体系的最新研究进展。
Here, the most recent progresses in the methylation studies of histone arginine were summa.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails.
结合以上去乙酞化酶抑制剂的实验结果，我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。
Combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation.
结合以上去乙酞化酶抑制剂的实验结果，我们认为组蛋白乙酞化修饰参与了热休克基因的表达调控。
Combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation.
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