组蛋白乙酰化促进基因表达，而去乙酰化则抑制基因表达。
Histone acetylation contributes to expression of gene, while histone deacetylation leads to repression of gene expression.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
组蛋白乙酰化修饰与基因的表达调控相关，参与了各种肺部疾病的病变过程。
The acetylation of histone is related to gene expression and regulation, which takes part in the pathological courses of all kinds of lung diseases.
本研究是对推测的小麦组蛋白乙酰转移酶及脱乙酰化酶基因功能研究的首次报道。
This is a first report about function study of histone acetyltransferase and deacetylase in wheat.
组蛋白乙酰化和去乙酰化可以改变染色质的结构，参与基因的表达调控和重编程。
Histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.
组蛋白乙酰化和去乙酰化可调节染色体的多种功能，例如基因表达和染色体分离等。
Histone acetylation and deacetylation can regulate many chromosome functions, such as gene expression and chromosome segregation.
如同阿尔茨海默病鼠，增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。
As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.
我们认为姜黄素的抗肿瘤作用，与其HAT抑制活性及对组蛋白乙酰化的诱导作用关系不大。
We believe that the effect of HAT inhibition and induction of histone hyperacetylation of curcumin plays little role in its anti-cancer effect.
目的观察dna甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。
Purpose to investigate the effects of DNA methylation and histone acetylation on the expression of tumor associated genes and cell cycle progression in human colonic cancer cells.
组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。
Histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。
In this paper, we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.
的突变在诊断或复发时获得的，和导致截断保守的氨基酸残基的组蛋白乙酰转移酶结构域的基因或有害的替代。
The mutations were either present at diagnosis or acquired at relapse, and resulted in truncated alleles or deleterious substitutions in conserved residues of the histone acetyltransferase domain.
结论P 38MAPK信号通路可能通过上调组蛋白乙酰化水平增加SH - SY5Y的APP蛋白表达。
Conclusion APP expression on SH-SY5Y cells may increase through up-regulation of histone acetylation through P38MAPK pathway.
这两种酶是组蛋白乙酰转移酶(它能给蛋白质添加乙酰基)和甲基化dna结合蛋白- 2(它能把DNA上的甲基去除)。
The enzymes in question are histone acetyltransferase (which adds acetyl groups to proteins) and methylated DNA-binding protein-2 (which removes methyl groups from DNA).
高脂肪组产的子鼠的葡萄糖代谢基因有些表观改变，组蛋白乙酰化环节——能打开DNA环使基因转录更容易——是其中一处改变。
The high-fat offspring also had epigenetic modifications to genes that regulate glucose metabolism.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
下面的视频是关于在癌症细胞里的常规基因表达是如何进行组蛋白乙酰化作用(acetylationofhistone)的。
Here's a video that animates the acetylation of histone proteins in the regulation of gene expression in cancer cells.
在2007年5月10日的自然杂志中，他们报道了一种促进组蛋白乙酰化的药物，它能增强阿耳茨海默氏病模型老鼠的学习和记忆能力。
In the 10 May 2007 issue of Nature, they reported that a drug that promotes histone acetylation improved learning and memory in a mouse model of Alzheimer's disease.
此外，组蛋白乙酰转移酶的活性对HIV的增殖是必要的，至少一个科学小组建议组蛋白乙酰转移酶或相似的酶做为靶点也许是抑制病毒一个新方式。
In addition, hat activity is necessary for the multiplication of HIV, leading at least one scientific group to suggest that targeting HATs or similar enzymes might be an new way to thwart the virus.
一个小小的分子称作一个乙酰基团，它黏在一个称作h4的特殊组蛋白上。
A small molecule called an acetyl group attaches to a particular histone known as H4.
它保证了H 4组蛋白有大量的乙酰基团粘附其上，所以环绕在组蛋白上的DNA能再次被翻译。
It ensures that the H4 histones have plenty of attached acetyl groups, so the DNA wrapped around the histone once again becomes available for transcription.
为了逆转记忆遗失，医生在复合物中添加了组蛋白脱乙酰基酶抑制物。
To reverse the memory loss, doctors inject a compound called a histone deacetylase inhibitor.
DNA周围的学习和记忆基因束靠近乙酰基群，注入一种能促进乙酰基群变成任何一种组蛋白分子的酶。
The cluster of learning and memory genes on the surrounding DNA ends up close to the acetyl group.
这种改性或者是甲基增至DNA中，或者是乙酰基增加到组蛋白中。
This modification is either the addition of methyl groups to the DNA or of acetyl groups to the histones.
这项刊登在《预防癌症研究》刊物中的研究结果也指出，女性摄取萝卜硫素后，不但癌细胞增长减缓，就连组蛋白脱乙酰酶活性也降低。
In the new study published in the journal cancer Prevention Research, the intake of sulforaphane did reduce HDAC activity, as well as cancer cell growth.
组蛋白尾端不同的化学修饰往往和基因的表达调控有着密切的关系，乙酰化就是常见的一种修饰形式。
Gene expression is often closely related to the different chemical modification ends of protein, acetylation is a kind of common form of modification.
乙酰化反应使组蛋白让DNA解螺旋，允许了基因的表达发生，因此抑制乙酰化反应将从总体上降低基因的表达。
Acetylation causes histones to unspool their DNA, thereby allowing gene expression to proceed—so decreased acetylation generally reduces gene expression.
乙酰化反应使组蛋白让DNA解螺旋，允许了基因的表达发生，因此抑制乙酰化反应将从总体上降低基因的表达。
Acetylation causes histones to unspool their DNA, thereby allowing gene expression to proceed—so decreased acetylation generally reduces gene expression.
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