最显著的神经病理改变是新纹状体中度多刺的神经元的优先丢失。
The most significant neuropathological change is a preferential loss of medium spiny neurons in the neostriatum.
结论移植的神经干细胞能在PD模型小鼠纹状体存活，并可分化出特定的多巴胺能神经元。
ConclusionsThe transplanted multipotent NSCs could survive, differentiate into functional dopamine neurons in the brains of PD model mice.
目的：研究古拉定、川芎嗪、丹参对6-羟基多巴胺（OHDA）处理后大鼠的黑质多巴胺（DA）神经元及纹状体细胞外液DA的影响。
Objective:To study the effect of glutathione (GSH), Ligustrazine and Salvia miltiorrhiza on dopamine (DA) and its metabolites of corpus striatum and DA neurons in rats injected with 6-OHDA.
纹状体中移植细胞主要分化为神经元和星形胶质细胞。
In striatum, the labeled cells differentiated into neurons and glias.
帕金森病是中枢神经系统常见的一种神经退行性疾病，是由于中脑多巴胺能神经元丢失，导致纹状体多巴胺分泌减少造成的一种老年人易患疾病。
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain and, consequently, depletion of dopamine in the striatum.
目的探讨纹状体组织对胚胎干细胞向多巴胺能神经元分化的定向诱导作用，及其细胞来源和诱导方式。
Objective To explore the inductive effect of striatal tissue on mouse embryonic stem cells and further analyse the cell source and inductive pattern of this inductive effect.
目的探讨纹状体组织对胚胎干细胞向多巴胺能神经元分化的定向诱导作用，及其细胞来源和诱导方式。
Objective To explore the inductive effect of striatal tissue on mouse embryonic stem cells and further analyse the cell source and inductive pattern of this inductive effect.
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