与之相反，L -甲硫氨酸增加了甲基化水平，从而减弱了正常老鼠中糖皮质激素受体基因的表达，导致了恐惧、焦虑和对压力的强烈反应。
By contrast, L-methionine increased the level of methylation and thus reduced the expression of the gene in animals with loving mothers, and led to fear, anxiety and a heightened response to stress.
结果：研究表明50岁及以上的女性服用TZD、糖皮质激素，髓袢利尿剂和自报活动受限的其骨折风险增加具有统计学意义。
RESULTS: We found statistically significant increased odds of exposure to TZDs, glucocorticoids, loop diuretics, and self-reported limited mobility for women 50 yr of age and older with fractures.
对不吸入糖皮质激素的患者来说，规律使用沙美特罗与规律使用沙丁胺醇相比，其致死性及非致死性严重不良事件的发生率并无显著增加。
Compared with regular salbutamol, regular salmeterol was not associated with a significant increase in fatal or nonfatal serious adverse events in patients not taking inhaled corticosteroids.
在男性，同时服用髓袢利尿剂、TZD、糖皮质激素和胰岛素并伴活动受限和下肢截肢的其骨折风险增加具有统计学意义。
Exposure to both loop diuretics and TZDs, glucocorticoids, and insulin and limited mobility and lower-extremity amputation were associated with fractures in men.
进一步的研究需要明确糖皮质激素的最佳剂量和治疗方法，比如儿童的用量，大多数对糖皮质激素的反应有效，则需要增加剂量。
Further studies are needed to identify the optimal dosage and duration of therapy, as well as pediatric subgroups, most likely to respond favorably to corticosteroids, the group adds.
进一步的研究需要明确糖皮质激素的最佳剂量和治疗方法，比如儿童的用量，大多数对糖皮质激素的反应有效，则需要增加剂量。
Further studies are needed to identify the optimal dosage and duration of therapy, as well as pediatric subgroups, most likely to respond favorably to corticosteroids, the group adds.
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