目的建立一种简便、实用的检测亚甲基四氢叶酸还原酶(MTHFR)等位基因C677 T点突变的方法，并初步观察部分健康老人和老年血管性痴呆(VD)患者中mthfr等位基因C677 T点突变情况。
Objective to establish a simple and practical method for detecting the MTHFR gene C677T mutation so as to investigate MTHFR genotypes in the healthy elder and Vascular Dementia (VD).
CYP2C9基因具有遗传多态性，在人类存在几种等位基因的突变体。
CYP2C9 gene has several mutant alleles leading to genetic polymorphisms in humans.
通过分析肿瘤细胞的密度及等位基因突变的几率来确定肿瘤异质性和等位基因特异性突变的不平衡性。
Tumor cellularity and mutant allele frequency were analyzed to identify tumor heterogeneity and mutant allele-specific imbalance.
等位基因突变几率预测肿瘤异质性方面低于预期，但等位基因突变几率预测等位基因特异性突变不平衡性方面则高于预期。
Lower than expected mutant allele frequency indicated tumor heterogeneity, while higher than expected mutant allele frequency indicated mutant allele-specific imbalance.
等位基因突变几率预测肿瘤异质性方面低于预期，但等位基因突变几率预测等位基因特异性突变不平衡性方面则高于预期。
Lower than expected mutant allele frequency indicated tumor heterogeneity, while higher than expected mutant allele frequency indicated mutant allele-specific imbalance.
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