本发明为一种穿心莲内酯软胶囊的制剂及其制备方法。
The present invention is one kind of soft andrographolide capsule preparation and its preparation process.
目的：设计和合成出新的穿心莲内酯衍生物并研究其抗肿瘤活性。
AIM: To study the synthesis and antitumor activity of the andrographolide derivatives.
用正交法对微波和超声波辅助提取穿心莲内酯的工艺条件进行优化。
Orthogonal experiments were used to find the optimal extraction process of andrographolide by microwave and ultrasonic assisted extraction.
结果：发现水浴蒸干会使脱水穿心莲内酯的色谱峰峰面积积分值大大降低。
Result:The tests results proved to us that the peak of Dehydroandrographolide would drop as the Dehydroan-drographolide CRS was evaporated in a water bath.
方法：用梯度洗脱法测定清火栀麦片中穿心莲内酯和脱水穿心莲内酯的含量。
METHODS Gradient elution method was used to determine the content of andrographolide and dehydroandrographolide in Qinghuo Zhimai tablets.
结论：本方法专属性好，简便快捷，可用于亚硫酸氢钠穿心莲内酯的质量控制。
Conclusion: This specific and efficient HPLC method can be used for the quality control of andrographolide sodium bisulfite.
目的：通过测定穿心莲内酯和脱水穿心莲内酯的含量来控制清火栀麦片的质量。
OBJECTIVE To control the quality of Qinghuo Zhimai tablets by determine the content of andrographolide and chrysophanol dehydroandrographolide.
本文探讨单独在穿心莲内酯的12位引入N -酰基氨甲基对其抗肿瘤活性的影响。
In this paper, we investigate the influence of antitumor activity by introducing N-Acylaminomethyl groups at C-12 of andrographolide.
路边青与穿心莲配伍使用可导致脱水穿心莲内酯的吸收慢、消除快、生物利用度低。
The use of Andrographis together with Clerodendron delayed the absorption, increased the clearance, and decreased the bioavailability of dehydroandrographolide.
方法：采用液中干燥法制备穿心莲内酯微囊，并按《中国药典》方法测定体外溶出度。
Method: andrographolide microcapsules were prepared by a solvent evaporation technique, and the dissolution of andrographolide microcapsules was determined by the method of ChP.
结论：该方法所制备微囊不仅可以有效掩盖穿心莲内酯的苦味，而且在胃液中能够快速释放。
Conclusion: the microcapsules prepared can mask the bitter taste of andrographolide, and quickly release in stomach.
本发明公开了一种穿心莲内酯滴丸及其制备方法，其中的穿心莲内酯加入适当辅料制成滴丸剂。
The invention discloses dripping pills of andrographolide and its preparing method, wherein the andrographolide is filed by right amount of findings to obtain drop pills.
目的考察注射用亚硫酸氢钠穿心莲内酯分别与5%葡萄糖注射液和0.9%氯化钠注射液配伍的稳定性及溶血性。
Objective To study the stability and hemolysis of andrographolide-sodium bisulfite injection mixed with 5% glucose and 0.9% sodium chloride injections.
方法：采用TLC法对处方中的薄荷、翠云草和穿心莲进行了鉴别；用HPLC法测定了方中脱水穿心莲内酯的含量。
Methods:Mentholum, Selaginella, Dehydroandrographolide in Cuilian Jiedu Tablets were identified by TLC, and the content of Dehydroandrographolide was determined by HPLC.
美国哥伦比亚大学和香港中文大学的研究人员发现：穿心莲提取物中的内酯成分具有杀死HIV - 1的作用。
Columbia University and Chinese University of Hong Kong researchers found that: Chuanxinlian Lactonization extract components have killed the role of HIV-1.
美国哥伦比亚大学和香港中文大学的研究人员发现：穿心莲提取物中的内酯成分具有杀死HIV - 1的作用。
Columbia University and Chinese University of Hong Kong researchers found that: Chuanxinlian Lactonization extract components have killed the role of HIV-1.
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