皮肤表现为表皮细胞嗜酸性坏死和基底层细胞空泡性变，表皮发生裂隙、大泡形成以及真皮淋巴细胞浸润。
The skin showed eosinophilic necrosis of epidermal cells, vacuolar degeneration of epidermal basal cells, epidermal cleft, bulla and lymphocytic infiltration of the dermis.
结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；
It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.
结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；
It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.
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