本文旨在探讨大鼠脑实质内远位触液神经元中5-HT1A受体的分布及其在神经病理性痛中的作用。
The present study aimed to explore the effects of 5-HT1A receptors in the distal cerebral spinal fluid-contacting neurons (CSF-CNs) in rat brain parenchyma in neuropathic pain.
方法：以L 5脊神经结扎制备大鼠神经病理性痛模型，利用分离背根单纤维细胞外电生理记录异位放电。
Methods: Using L5 spinal nerve ligation as neuropathic pain model of rats, teased fiber recording technique was used to explore the property of ectopic discharges.
行为学结果显示，阻断外周5-HT_（2A）受体能够明显抑制慢性炎症及神经病理性痛引发的热痛觉过敏。
The behavior results showed that blocking peripheral 5-HT_(2A)receptors inhibited the thermal hyperalgesia in inflammatory and neuropathic pain.
为了观察坐骨神经损伤(SNI)后小鼠全脑环氧合酶(COX) -1和COX - 2的表达变化，以及不同选择性的COX抑制剂对SNI所致神经病理性痛的效应。
To observe the expression of cyclooxygenase (COX) -1 and COX-2 in brain after spared nerve injury (SNI) and compare the analgesic effects of COX inhibitors with different selectivity.
为了观察坐骨神经损伤(SNI)后小鼠全脑环氧合酶(COX) -1和COX - 2的表达变化，以及不同选择性的COX抑制剂对SNI所致神经病理性痛的效应。
To observe the expression of cyclooxygenase (COX) -1 and COX-2 in brain after spared nerve injury (SNI) and compare the analgesic effects of COX inhibitors with different selectivity.
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