因为其指定的神经氨酸酶遗传密码——H 1 N 1中的N1——控制着被感染细胞的病毒扩散。
It codes for the neuraminidase enzyme - the N1 in H1N1 - which controls the expansion of the virus from infected cells.
其次是另一种表面蛋白神经氨酸酶（见 “转移攻击 ” ）。
The next big target is another surface protein, neuraminidase (see "Moving target").
为了克服耐药性，科学家正在神经氨酸酶上寻找一个替代的位置，并针对其开发新药。
To overcome drug resistance, researchers are searching for alternative sites on neuraminidase against which new drugs can be targeted.
就神经氨酸酶抑制剂而言，有一些重大的限制因素，主要是生产能力有限，同时，在许多国家，其价格高得难以负担。
For the neuraminidase inhibitors, the main constraints - which are substantial - involve limited production capacity and a price that is prohibitively high for many countries.
这些药物抑制一种叫做神经氨酸酐酶的酶，这种酶可以促使新生成的病毒离开被感染的细胞向周身散播。
These drugs act against an enzyme called neuraminidase, which allows newly formed viruses to leave infected cells and spread around the body.
到目前为止，对神经氨酸酶抑制剂的抗病毒制剂耐药性，在临床上很微弱，但在大流行期间广泛使用这类抑制剂时可能会出现。
Antiviral resistance to neuraminidase inhibitors has been clinically negligible so far but is likely to be detected during widespread use during a pandemic.
H5N1病毒预期对神经氨酸酶抑制剂敏感。
The H5N1 virus is expected to be susceptible to the neuraminidase inhibitors.
神经氨酸酶抑制剂的疗效特别取决于其早期使用(在症状出现后48小时之内)。
The efficacy of the neuraminidase inhibitors depends, among others, on their early administration (within 48 hours after symptom onset).
这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。
There are two classes of such medicines, 1) adamantanes (amantadine and remantadine), and 2) inhibitors of influenza neuraminidase (oseltamivir and zanamivir).
增加EGR1表达可以激活其他信号分子的转录，包括CDK5和酪氨酸羟化酶，对神经细胞生长和分化有长期影响(2,3)。
Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2, 3).
结论：NURR1基因结合神经干细胞有效改善了帕金森病模型症状，提高移植后酪氨酸羟化酶阳性神经元细胞的数量。
CONCLUSION: NURR1 gene combined with NSC can effectively ameliorate PD models symptoms and elevate the number of tyrosine hydroxylase positive neurons after transplantation.
扎那米韦和奥塞·米韦结合在神经氨酸酶的不同催化位点，这就导致了这种耐药情况不同的发生。
Zanamivir and oseltamivir bind differently at the neuraminidase catalytic site and this contributes to different drug resistance profiles.
M6的胶体金复合物不能与经胰酶和神经氨酸酶处理过的红细胞发生结合。
M6 gold complexes showed no ability to bind to surface of erythrocytes treated by trypsin or neuraminidase.
目的：从噬菌体呈现12肽库中筛选与流感病毒神经氨酸酶特异性结合的肽。
Objective: to select the peptide binding to influenza virus neuraminidase from phage display 12 peptide library.
目的：探讨脑出血后抑郁动物模型脑内单胺神经递质5 -羟色胺、去甲肾上腺素、酪氨酸羟化酶的变化，研究中药颐脑解郁方对脑出血后抑郁的干预机理。
Objective: to observed the change of 5-ht, ne, th in rat brain of post hemorrhaged depression and the function of traditional medicine YINAOJIEYU to the rat of post hemorrhaged depression.
实验大鼠接受两次肝素酶III注射以消化HS，或两次神经氨酸酶注射以除去神经氨酸（阳性对照）。
Rats received two intravenous injections of either heparinase III to digest HS or neuraminidase to remove neuraminic acids (positive control).
方法给一类酪氨酸脱氢酶阳性的神经细胞（一种中枢神经源细胞），又称CAD细胞，引入由DNA编码的野生型和突变型离子通道。
Methods To introduce DNA encoding the wild- type and mutant channel into immortalized tyrosine hydroxylase- positive CNS- derived neurons, CAD cells.
神经氨酸酶（NA）是流感病毒表面的一种重要蛋白质，在免疫和致病方面起重要作用。
Neuraminidase (NA) is an important protein on the surface of virion and plays an important role in immune and lethality.
结论吡咯烷类化合物对神经氨酸酶有较高的抑制活性，值得进一步研究。
CONCLUSION Pyrrolidine derivatives exhibited potent neuraminidase inhibitory activities, and is worth of further investigation.
目的合成新型吡咯烷类神经氨酸酶抑制剂，并测定其抑制神经氨酸酶的活性。
OBJECTIVE To synthesize a series of novel pyrrolidine derivatives as neuraminidase inhibitors and test their inhibitory activities against neuraminidase.
同时提醒关注神经氨酸酶抑制剂应用的耐药问题。
Simultaneously, physician should pay attention to the resistance of neuraminidase inhibitor.
结果表明神经氨酸酶是Hps的主要免疫保护性抗原之一，为进一步研究Hps亚单位疫苗提供理论依据。
The result show that, neuraminidase is one of the main immune protective antigen for the Hps, which provides a theoretical basis for further study of the Hps subunit vaccine.
方法以L -羟脯氨酸为原料，合成一系列神经氨酸酶抑制剂，并用高通量活性筛选方法检测其对神经氨酸酶的抑制活性。
METHODS a series of pyrrolidine derivatives were synthesized from L-hydroxyproline, and the neuraminidase inhibitory activities of these compounds were tested using high throughput screening.
结论黄芩甙对我国分离的甲型流感病毒神经氨酸酶具有抑制活性的作用。
Conclusion Baicalin had inhibition effect on the strain of influenza virus isolated in China.
证实了大孔吸附树脂吸附法纯化的微生物发酵液中小分子化合物粗提物具有不同程度的流感病毒神经氨酸酶抑制活性。
The small molecules can be greatly enriched and the amount of fermentation liquid required in resin purification method is much less than that of organic reagent extraction.
证实了大孔吸附树脂吸附法纯化的微生物发酵液中小分子化合物粗提物具有不同程度的流感病毒神经氨酸酶抑制活性。
The small molecules can be greatly enriched and the amount of fermentation liquid required in resin purification method is much less than that of organic reagent extraction.
应用推荐