H5N1病毒预期对神经氨酸酶抑制剂敏感。
The H5N1 virus is expected to be susceptible to the neuraminidase inhibitors.
同时提醒关注神经氨酸酶抑制剂应用的耐药问题。
Simultaneously, physician should pay attention to the resistance of neuraminidase inhibitor.
目的合成新型吡咯烷类神经氨酸酶抑制剂，并测定其抑制神经氨酸酶的活性。
OBJECTIVE To synthesize a series of novel pyrrolidine derivatives as neuraminidase inhibitors and test their inhibitory activities against neuraminidase.
神经氨酸酶抑制剂的疗效特别取决于其早期使用(在症状出现后48小时之内)。
The efficacy of the neuraminidase inhibitors depends, among others, on their early administration (within 48 hours after symptom onset).
就神经氨酸酶抑制剂而言，有一些重大的限制因素，主要是生产能力有限，同时，在许多国家，其价格高得难以负担。
For the neuraminidase inhibitors, the main constraints - which are substantial - involve limited production capacity and a price that is prohibitively high for many countries.
这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。
There are two classes of such medicines, 1) adamantanes (amantadine and remantadine), and 2) inhibitors of influenza neuraminidase (oseltamivir and zanamivir).
方法以L -羟脯氨酸为原料，合成一系列神经氨酸酶抑制剂，并用高通量活性筛选方法检测其对神经氨酸酶的抑制活性。
METHODS a series of pyrrolidine derivatives were synthesized from L-hydroxyproline, and the neuraminidase inhibitory activities of these compounds were tested using high throughput screening.
到目前为止，对神经氨酸酶抑制剂的抗病毒制剂耐药性，在临床上很微弱，但在大流行期间广泛使用这类抑制剂时可能会出现。
Antiviral resistance to neuraminidase inhibitors has been clinically negligible so far but is likely to be detected during widespread use during a pandemic.
到目前为止，对神经氨酸酶抑制剂的抗病毒制剂耐药性，在临床上很微弱，但在大流行期间广泛使用这类抑制剂时可能会出现。
Antiviral resistance to neuraminidase inhibitors has been clinically negligible so far but is likely to be detected during widespread use during a pandemic.
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