目的合成碳青霉烯类抗生素美罗培南。
Aim To synthesize meropenem trihydrate, a carbapenem antibiotic.
碳青霉烯类通常在紧急情况时才使用，用于细菌对常用的抗生素产生耐药性之后。
The carbapenems are normally kept for emergencies and used when bacteria is found to be resistant to more commonly prescribed antibiotics.
该基因使细菌对碳青霉烯类（carbapenems）抗生素产生耐药性。
The gene made the bacteria resistant to the group of antibiotics called carbapenems.
本课题概述了碳青霉烯类抗生素的研究进展，并设计合成了比阿培南的侧链中间体。
This paper studied some of the highlights in the progress of the research of carbapenem antibiotics, designed and mainly synthesized branched chain intermediate of biapenem.
由于碳青霉烯类抗生素原料合成难度大、工艺复杂，该类药物在我国上市的品种不多。
Because carbapenems are difficult to synthesize antibiotics, complex, such drugs listed in the breed.
研究样本收集于2013至2014年。所发现的超级细菌是耐碳青霉烯类肠杆菌，简称CRE。
The samples were collected between 2013 and 2014. The superbug found was carbapenem-resistant Enterobacteriaceae, or CRE.
目的研究碳青霉烯类化合物的定量构效关系(Q SAR)，并进行新的碳青霉烯类化合物的分子设计。
Objective To study the quantitative structure-activity relationship (QSAR) of carbapenems and the design of new compounds.
NDM-1可存在于不同种类的细菌中，甚至对最强大的抗生素之一、碳青霉烯类抗生素也能产生抗药性。
NDM-1 can exist inside different bacteria, and it makes them resistant to even the most powerful antibiotics - carbapenems.
大肠埃希菌对碳青霉烯类、头霉素类、丁胺卡那和呋喃妥因的耐药率较低，而肺炎克雷伯菌对多种抗菌药物具有较好的敏感性。
E. coli showed low drug resistance ratio to carbapenem, cephamycins, amikacin and furadantin, and Klebsiella pneumoniae showed a good sensitivity to most of the antibiotics.
这种"超级病菌"能够产生名为NDM-1的酶，而NDM-1可存在于不同种类的细菌中，甚至对最强大的抗生素—碳青霉烯类抗生素也能产生抗药性。
The "superbug" make an enzyme called NDM-1, whic can exist inside different bacteria, and it makes them resistant to even the most powerful antibiotics - carbapenems.
碳青霉烯类药物在2005年、2006年度保持95%以上的敏感率，2007年开始其敏感性急剧下降，2008年敏感率只有30%；
The carbon blue mildew alkenes medicine in 2005,2006 year maintains 95% above sensitive rate, in 2007 starts its sensitivity to drop suddenly, in 2008 sensitive rate has 30%;
研究人员还鉴定出北京雾霾的元基因组中含有几种具有碳青霉烯类抗药性的基因，碳青霉烯类是用于治疗具有挑战性细菌感染最后求助的抗生素。
The researchers also identified in the Beijing smog metagenomes that contained several genes resistant to carbapenems, a class of last-resort antibiotics for treating challenging bacterial infections.
研究人员还鉴定出北京雾霾的元基因组中含有几种具有碳青霉烯类抗药性的基因，碳青霉烯类是用于治疗具有挑战性细菌感染最后求助的抗生素。
The researchers also identified in the Beijing smog metagenomes that contained several genes resistant to carbapenems, a class of last-resort antibiotics for treating challenging bacterial infections.
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