目的利用组织工程技术体外重建角膜上皮组织，为眼表重建提供良好的移植材料及方法。
Objective To reconstruct corneal epithelium in vitro by tissue engineering technique and provide effective method and materials for clinical transplantation.
干眼泪腺和眼表上皮细胞的凋亡异常增加，而局部组织中的淋巴细胞的凋亡却被抑制。
Apoptosis in lacrimal gland and ocular surface epithelium increase abnormally, but in local lymphocytic cell is inhibitted in dry eye .
结论糖尿病导致的泪腺、角膜、结膜等眼组织破坏是糖尿病性眼表病变的病理基础。
Conclusions Diabetes can cause lacrimal gland, corneal and conjunctival tissue damage, which is the pathological foundation of the diabetic ocular surface disease.
本文将介绍上述组织工程材料在眼表重建实验和临床应用的研究现状及进展。
This review interpreted the researches status quo and advances in ocular surface reconstruction experiment and clinical application.
方法取患眼健康象限或对侧眼浅层角膜或角结膜组织为供体，为16只瞳孔区角膜斑翳或因烧伤发生自溶性溃疡的角膜作自体眼表移植术。
Methods Ocular surface autografting was performed on 16 eyes with donor tissue either from healthy quadrants of the same eye or from the contralateral eye.
方法取患眼健康象限或对侧眼浅层角膜或角结膜组织为供体，为16只瞳孔区角膜斑翳或因烧伤发生自溶性溃疡的角膜作自体眼表移植术。
Methods Ocular surface autografting was performed on 16 eyes with donor tissue either from healthy quadrants of the same eye or from the contralateral eye.
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