实验以盐酸胍作为阳性对照药。
包涵体通过6M盐酸胍裂解后，利用镍离子亲和树脂进行纯化。
The inclusion body was solubilized by 6m Guanidine hydrochloric acid and purified by ProBondTM Resin.
用荧光相图法分别研究了脲和盐酸胍诱导卵清溶菌酶去折叠的过程。
The unfolding of hen egg white lysozyme induced by urea and guanidine hydrochloride (GuHCl) has been studied by "phase diagram" method of fluorescence.
用荧光相图法分别研究了脲和盐酸胍诱导牛肝过氧化氢酶去折叠的过程。
The unfolding of bovine liver catalase induced by urea or guanidine hydrochloride (GuHCl) has been studied by "phase diagram" method of fluorescence.
本文利用荧光、紫外差光谱研究了根霉葡萄糖淀粉酶在盐酸胍变性后的复性、复活动力学。
The kinetics of the renaturation and reactivation of glucoamylase denatured by guanidine HCl was determined by means of the UV differential absorbance measurement and fluorescence emission spectra.
目的观测人胎盘碱性磷酸酶（HPAP）在盐酸胍变性和复性过程中构象与活力的变化，探讨其折叠机制。
Objective To examine the changes of conformation and activity of human placental alkaline phosphatase(HPAP) in denaturation and renaturation of guanidine chloride, and to study its folding mechanism.
在高浓度盐酸胍下酶失活主要是因为酶二聚体迅速解离成单亚基的过程和单亚基构象逐渐变化的缓慢过程。
The inactivation of aminoacylase in guanidine solution was caused by rapid dissociation of dimer into monomer which was then slowly changed into a stable conformation.
目的对盐酸二甲双胍缓释片体外释放度相关因素进行研究。
Objective to study on the factors involved in the release rate of metformin hydrochloride in vitro sustained-release tablets.
结论本释放度方法简单，快速，可用于盐酸二甲双胍缓释片体外释放度测定。
Conclusions the determination method is simple and swift, and can be applied in the determination of in vitro release rate of metformin hydrochloride sustained-release tablets.
以吗啉和盐酸为原料合成盐酸吗啉，使其与双氰胺反应制备盐酸吗啉脒胍。
Morpholine hydrochloride was synthesized from morpholine and hydrochloric acid, then reacted with dicyandiamide, and obtained moroxydine hydrochloride.
本法用于盐酸吗啉胍片及杀菌剂中盐酸吗啉胍的定量分析，结果满意。
The recommended method has been successfully used for the analysis of tablets of moroxydine hydrochloride and bactericide.
方法：以氨基乙醛缩甲醇制备的N （2 ，2二甲氧基乙基）胍硫酸盐经盐酸催化环合制得2 氨基咪唑硫酸盐。
METHODS:N (2,2 dimethoxylethyl)guanidine sulfate from aminoacetaldehyde dimethyl acetal was treated with concentrated HCl to get 2 aminoimidazole sulfate.
结论：本方法准确、快速、简便，可不经分离直接测定复方盐酸二甲双胍片中盐酸二甲双胍的含量。
CONCLUSION: the method is accurate, fast, convenient, and which can be used to determine the contents of metformin hydrochloride in compound metformin hydrochloride tablets directly without isolation.
盐酸二甲双胍是目前广泛用于临床医学的双胍类降糖药。
Metformin hydrochloride is an orally administered biguanide widely used in clinical medicine.
随着盐酸吗啉胍处理浓度的增加，有丝分裂指数降低，而微核率和染色体畸变率均升高；
The cell mitotic index decreased when the concentration of MH increased in a certain range, however, the ratios of micronucleus and chromosome aberration could increase.
方法用紫外分光光度法测定该制剂中盐酸二甲双胍的含量，高效液相色谱法测定格列吡嗪的含量。
Methods The content of dimethydiguanide was determined by ultraviolet spectrophotometry, and the content of glipizide was determined by high-performance liquid chromatography(HPLC).
本文采用流化床技术制备盐酸二甲双胍素丸，并采用缓释包衣材料制备缓释盐酸二甲双胍微丸。
In this thesis, Metformin Hydrochloride pellets and sustained-release pellets were prepared by powder coating technology.
优选由那格列奈速释层与盐酸二甲双胍缓释层组成的双层片处方。
To optimize the formula of the double-layer tablet of nateglinide rapid-release layer and metformin hydrochloride sustained-release layer.
目的比较几种以盐酸聚六亚甲基双胍为主要成分的消毒剂杀灭白色念珠菌的效果。
Objective To compare the efficacy of four kinds of polyhexamethylene biguanidine compound disinfection solutions in killing Candida albicans.
制备膜控释盐酸二甲双胍缓释片并对其体外释放度的相关影响因素进行研究。
The membrane controlled-release coated tablets of metformin hydrochloride were prepared by coating method and the factors involved in the release rate of metformin hydrochloride in vitro were studied.
目的探讨盐酸二甲双胍缓释片治疗2型糖尿病患者的临床效果和安全性。
Metformin hydrochloride sustained-release tablets and rosiglitazone maleate tablets in the treatment of type 2 diabetes.
缓释制剂中格列吡嗪和盐酸二甲双胍的重量比范围1∶100至1∶200，最优比例为1∶100，制剂中加入适量药用辅料。
The weight ratio of glipizide to metformin hydrochloride is 1 : 100-200, the best ratio is 1:100 and it adds a proper amount of medicinal auxiliary to the preparation.
目的：研制复方盐酸二甲双胍缓释胶囊，并对盐酸二甲双胍(MH)和格列美脲进行释放度研究。
Objective: To prepare compound metformin hydrochloride sustained-release capsules, and investigate the release behavior of metformin hydrochloride (MH) and glimepiride.
本发明为化学合成领域的盐酸二甲双胍精制方法。
The invention provides a method for refining metformin hydrochloride in the technical field of chemical synthesis.
得到的盐酸二甲双胍 的澄清度合格，合格率为100％，符合要求。
The obtained metformin hydrochloride is qualified in clarity with a qualification rate of 100 percent, and satisfies requirement.
二甲双胍盐酸盐和钼酸铵等具备较大的生产能力，具有较高市场份额。
Metformin hydrochloride and ammonium molybdate are retaining high producing power and market shares, there are the other tens kinds of medicine intermediates on researching .
目的改进对-胍基苯甲酸盐酸盐合成工艺。
OBJECTIVE To improve the synthetic process of 4-guanidinobenzoic acid.
本发明公开了一种双胍类抗糖尿病药物，特别是盐酸二甲双胍的肠溶药物组合物。
The invention discloses a biguanide anti-diabetes medicine, in particular to a metformin hydrochloride enteric-coated medicine compound.
本发明公开了一种双胍类抗糖尿病药物，特别是盐酸二甲双胍的肠溶药物组合物。
The invention discloses a biguanide anti-diabetes medicine, in particular to a metformin hydrochloride enteric-coated medicine compound.
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