方法采用HSC-T6肝星状细胞系作为活化的肝星状细胞的研究模型。
Methods HSC-T6 rat hepatic stellate cell line was chosen as the study model of the activated hepatic stellate cells.
方法采用HSC - T6肝星状细胞系作为活化的肝星状细胞的研究模型。
Methods HSC-T6 hepatic stellate cell line was chosen as the study model of the activated hepatic stellate cells.
目的：为深入探讨肝纤维化的细胞机制，探索经济、稳定的肝星状细胞分离和培养方法。
Objective: To investigate the method of isolation and culture of hepatic stellate cells for studying the cellular mechanisms of hepatic fibrosis.
肝星状细胞是一种与肝纤维化密切相关的主要的细胞种类，它在肝受到损伤时形成瘢痕组织。
HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.
国际肝病：除了肝星状细胞在肝纤维化发生中的重要作用，还有哪些机制参与了肝纤维化的发生？
International Hepatology: Besides the important role of hepatic stellate cell in liver fibrosis development, are there any other important mechanisms involving liver fibrosis development?
目的探讨雌二醇对肝星状细胞的影响及其可能的作用途径。
Objective To analyze the effect of estradiol on the function of hepatic stellate cells.
姜黄素对肝星状细胞增殖与凋亡的影响。
Effect of curcumin on proliferation and apoptosis of hepatic stellate cell line.
请您给我们介绍一下抗肝纤维化药物对于肝星状细胞的可能的作用机制？
Would you please give us a brief introduction on the possible strategies to target HSCs using anti-fibrotic agents?
肝星状细胞、成纤维细胞和窦状隙内皮细胞是肝内ctgf的重要来源。
It can be concluded that CTGF was mainly produced in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts.
门静脉肌成纤维细胞具有高度的增殖能力，而且，这些肌成纤维细胞来源于肝星状细胞，因此它们较容易发生凋亡，同时造成分离上的困难。
Portal myofibroblasts are highly proliferative and those myofibroblasts derived from hepatic stellate cells are relatively easily apoptotic and with this limited in their separation.
目的研究肝星状细胞(HSC)与肝纤维化和肝硬化的关系。
Objective To investigate the relationship between hepatic fibrosis and hepatic stellate cell (HSC).
我们知道肝星状细胞还是纤维化过程中细胞外基质的主要来源。
We know that hepatic stellate cells are still the major source of extracellular matrix during fibrogenesis.
肝星状细胞的激活、表型改变并分泌大量的细胞外基质是肝纤维化发生的中心环节。
The activation of hepatic stellate cell phenotype change and secretion of extracellular matrix of liver fibrosis is the central link.
目的：在大鼠小肝移植模型的基础上，检测大鼠小肝移植中肝星状细胞的激活在供肝损伤中所起的作用。
AIM: To investigate the role of the activation of hepatic stellate cells in small-for-size graft injury in a rat liver transplantation model.
目的：探讨甘草酸对大鼠肝星状细胞增殖、活化与细胞外基质合成的影响。
Objective: To investigate the role of glycyrrhizin on proliferation, activation, synthesis of extracellular matrix in rat hepatic stellate cell.
目的研究去甲基雏菊叶龙胆酮（DMB）对肝星状细胞（HSC）活化的影响及其机制。
Objective To investigate the effects of demethylbellidifolin(DMB) on activation of hepatic stellate cells(HSC) and its underlying mechanism.
目的观察中药复方861对体外培养肝星状细胞增殖及胶原合成的影响。
Aim the effect of compound 861 (Cpd 861) on rat hepatic stellate cell (HSC) proliferation and collagen synthesis in vitro was observed.
目的研究生长抑素类似物奥曲肽(oct)对体外培养的大鼠肝星状细胞(HSC)中结缔组织生长因子(CTGF)基因表达的影响。
ObjectiveTo investigate the effect of somatostatin analogue-octreotide (oct) on expression of connective tissue growth factor (CTGF) gene of murine hepatic stellate cells (HSCs) in vitro.
目的了解内毒素受体在肝星状细胞活化中的变化和作用。
Objective to investigate the role of endotoxin receptor expression in the activation of hepatic stellate cells.
控制肝星状细胞的激活和增殖并逆肝纤维化的进程是抗肝纤维化研究的重点之一。
The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.
目的观察大黄(庶虫)虫丸对大鼠肝星状细胞活化及增殖的影响。
Objective To observe the effect of Dahuang Zhechong Pill (DZP) on activation and proliferation of hepatic stellate cells in rats.
目的：初步探讨JNK信号通路调控乙醛刺激的大鼠肝星状细胞（HSC）增殖的分子机制。
Objective: To explore the mechanism of JNK pathway regulating proliferation of hepatic stellate cells(HSC) stimulated by acetaldehyde.
目的：探讨牛磺酸在体外培养的大鼠肝星状细胞(hsc)的抗氧化作用。
Objective To investigate the anti-oxidative stress effects of Taurine on rat hepatic stellate cells (HSC) cultured in vitro.
目的观察大黄蔗虫丸对大鼠肝星状细胞活化及增殖的影响。
Objective To investigate the effects of Dahuang-Zhechong Pill on the Activation and proliferation of normal rat HSC.
目的观察重组大鼠肝再生增强因子(alr)对肝星状细胞株ig12增殖及细胞外基质合成的影响，探讨其抗肝纤维化作用的可能机制。
Objective To observe the effects of recombinant augmenter of liver regeneration (ALR) on the proliferation of hepatic stellate cell line IG12 and ECM synthesis.
目的研究黄芪总提物(TEA)对体外肝星状细胞增殖和产生胶原的影响。
Aim to study the effects of total extract of astragalus (TEA) on activating the primary cultured hepatic stellate cells (HSC) and synthesizing collagen.
目的研究玉郎伞多糖(YLS)对肝星状细胞(hsc)氧应激脂质过氧化作用的影响及机制。
Objective To study the effects and its mechanism of Yulangsan polysaccharide (YLS) on the proliferation and collagen I production of hepatic stellate cell (HSC) induced by oxidative stress.
结论：甘草甜素能诱导肝星状细胞铁蛋白重链的表达。调控铁蛋白重链基因的表达可能是甘草甜素抗肝纤维化作用的分子生物学机制之一。
Conclusion: glycyrrhizin could up-regulate the expression of ferritin heavy chain gene in hepatic stellate cells, which may contribute to the anti fibrosis of glycyrrhizin.
目的：在精密肝切片中利用乙醛激活肝星状细胞，建立一种星状细胞激活的体外模型，为研究和筛选阻抑肝纤维化发生的药物奠定基础。
AIM: To activate hepatic stellate cells (HSC) in vitro in precision-cut liver slices (PCLS) stimulated by acetaldehyde for studying and screening anti-fibrotic drugs.
结论：分离出的大鼠肝星状细胞产量高、活性高、纯度高。
Conclusions: Getting high output and purity hepatic stellate cells.
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