生发中心的树突状细胞可以内吞这种抗原物质并将其呈递给T 细胞,从而激活它们。
Dendritic cells in the germinal center may endocytose such antigenic material and present it to T cells, activating them.
结果:脾脏与扁桃体的树突状细胞胞浆能够被CR 2抗体强烈染色。
RESULTS: the follicular dendritic cells (FDC) in the spleen and tonsil tissues were intensely stained by CR2 antibodies.
组蛋白去乙酰酶抑制剂降低抗原提呈小鼠骨髓来源的树突状细胞的活性。
Histone deacetylase inhibitors decrease the antigen presenting activity of murine bone marrow derived dendritic cells.
这些大的树突状细胞具有巨噬细胞表型特征,包括强烈的HLA-DR表达。
This highly dendritic cell of the dermis possesses phenotypic characteristics of macrophages, including strong HLA-DR expression.
正常的树突状细胞会把异源体递呈给T细胞使其产生杀伤性T淋巴细胞来摧毁它。
Normally dendritic cells show an invader to T cells which produce cytotoxic T cells to destroy it.
当使用大量的树突状细胞时,和对照组的小鼠相比,肿瘤生长的抑制效果达到41%。
When large numbers of DCs were used, tumor growth was suppressed up to 41% when compared to control mice.
SOCS1沉默的树突状细胞能够促进自身成熟并增强其诱导的T细胞的抗肿瘤活性。
SOCS1 silent DC could promote DC maturity and enhance the antitumor response of t cell.
抗原刺激的树突状细胞的免疫调节功能在肿瘤患者和慢性病毒感染的动物模型中已有报道。
The immune modulator capacity of antigen-pulsed dendritic cells (DC) has been documented in patients with cancers and in animal models of chronic viral infections.
结论骨髓间充质干细胞上清可抑制单核细胞来源的树突状细胞的成熟和功能,诱导免疫耐受。
Conclusion Human bone marrow mesenchymal stem cells inhibit maturation and function of monocyte-derived dendritic cells and induce immune tolerance.
与此形成对照的是,容易形成艾滋病的人类和恒河猴的树突状细胞很容易被HIV和SIV激活。
In contrast, the easy form of human AIDS and rhesus monkeys dendritic cells can easily be activated HIV and SIV.
目的:探讨致敏的树突状细胞(DC)激活的肿瘤浸润淋巴细胞(TIL)体外抗小鼠乳腺癌活性。
Objective: To investigate the activities of tumor infiltrating lymphocytes(TILs) stimulated by dendritic cells(DCs) on mouse breast cancer cells in vitro.
单用DNA疫苗或联用TLR免疫的组间的树突状细胞表面上的共刺激分子的表达水平没有统计学上的显著差异。
No statistically significant difference in the expression levels of co-stimulatory molecules on dendritic cells surface between the groups immunized with DNA vaccine alone or with TLRs.
目的探讨肿瘤多肽致敏的白介素12 (IL 12 )基因修饰的树突状细胞(DC)对自发性肺转移癌的治疗作用。
Objective To investigate the treatment of spontaneous metastatic lung cancer by tumor antigen-pulsed, interleukin-12(IL-12) gene-modified dendritic cells (DC).
目的:应用黑色素瘤基因(MAGE-1)多肽负载的树突状细胞(DC)在体外诱导出高度特异性的抗肝癌免疫应答。
Objective: To induce efficient and specific anti-human hepatocellular carcinoma(HCC) immunological response in vitro by DC pulsed with MAGE-1 nonapeptide.
方法:根据细胞的黏附性不同,建立了一整套简便的树突状细胞的体外扩增方法,并利用HE染色和FACS研究了其生物学特征。
Methods According to the difference of cells s adhesion, a series of method were set up to generate DC and the biological characteristics were studied by he staining and FACS.
目的:探讨负载肿瘤抗原的树突状细胞(DC)疫苗诱导的细胞毒性T淋巴细胞(CTL)的体外杀瘤作用及对荷瘤小鼠的治疗作用。
Objective: to explore the anti-tumor effects of cytotoxic of T-lymphocytes (CTL) induced by dendritic cells (DC) vaccine loaded with tumor antigen.
目的:探讨改善外周血来源的树突状细胞(DC)体外培养的方法,以促进DC的成熟并提高其递呈抗原和激发特异性免疫反应的能力。
PART I The Improvement of Dendritic Cell Culture Measures in vitroObjective: Improve the measures of dendritic cell culture in vitro, to increase the rate of mature and function of DC.
结果表明:乳腺癌组织中散在分布S100蛋白阳性的树突状细胞,而癌周及癌旁的淋巴细胞及浆细胞密集区可见树突状细胞成簇存在。
The result showed that S100 protein positive dendritic cells distributed sparsely in malignant cells and formed a cluster among lymph cells and plasma cells.
目的探讨由动员人外周造血祖细胞体外培养扩增获得的树突状细胞(DC)的生物学特性,为临床应用肿瘤树突状细胞疫苗建立制备方法。
Objective to obtain dendritic cells (DCs) from peripheral blood stem cells and hematopoietic precursor cells in vitro, and assess the feasibility of clinical application of tumor vaccine.
结论:得到了一群较高程度表达CD 83、CD 86和HLA - DR分子、体外可强烈激发同种异体t淋巴细胞增殖的树突状细胞群。
CONCLUSION: a group of dendritic cells, which highly express CD83, CD86 and HLA-DR molecules, and stimulate strongly allogeneic t lymphocyte proliferation in vitro, are obtained.
目的探讨白细胞介素23 (IL - 23)基因转染的树突状细胞(DC)负载凋亡癌细胞抗原后诱导的免疫应答对小鼠胰腺癌的治疗作用。
Objective to investigate the therapeutic effects on pancreatic carcinoma by dendritic cells (DCs) transfected with interleukin (IL) -23 and acquiring apoptotic cell antigen.
目的:研究小鼠骨髓干细胞体外诱导分化的树突状细胞对T细胞增殖的影响,为进一步研究树突状细胞的功能及临床肿瘤的治疗提供有效的实验方法。
Objective To study the effects of mature dendritic cells (DCs) derived from mouse bone marrow on T cell proliferation in vitro, and provide techinological methods for tumor therapy.
目 的观察体外构建的榄香烯复合瘤苗抗原-卡介苗 热休克蛋白70复合物(HTA-HSP70BCG)诱导 的树突状细胞疫苗 的抗肿瘤效应。
Objective To investigate antitumor effects induced by dendritic cells (DCs) pulsed with complex of tumor antigen from elemene-combo tumor cell vaccine-heat shock protein 70 of BCG (HTA-HSP70BCG).
方法根据不同时期树突状细胞的粘附性质不同,设计简便的树突状细胞的体外扩增和纯化方法,并利用瑞氏染色和流式细胞仪(FACS)鉴定其生物学特征。
Methods According to different adhesiveness of DC in vary period, a simple method was used to generate and purificate DC, and their biology character were identified by Wright staining and FACS.
1973年,他发现了树突状细胞,这种细胞因为伸出类似于神经细胞树突的小突起而得名,这种结构也和它们的功能有关。
In 1973, he discovered the dendritic cell - so named because it has little tails, like dendrites in neurons - and set about explaining their function.
斯坦曼证明树突状细胞可激活T细胞——在适应性免疫反应中发挥重要作用的一类白细胞。
Steinman proved that dendritic cells activate t cells, a class of white blood cells that are important in adaptive immunity.
目的探讨胸腺树突状细胞的分布及数量与不同种属的关系。
Objective To study the relationship between quantity and distribution of thymus dendritic cells in various species.
目的观察小鼠胸腺树突状细胞(TDC)的形态。
Objective To observe the morphology of mouse thymic dendritic cells (TDC).
梭形细胞黑色素瘤和指状突树突细胞肉瘤:它们代表相同的过程吗?
Spindle Cell Melanoma and Interdigitating Dendritic Cell Sarcoma: Do They Represent the Same Process?
青藤碱的抗类风湿作用可能与其抑制树突状细胞分泌白细胞介素12有关。
The therapeutic effect of sinomenine on rheumatoid arthritis may be related to its inhibition to secretion of IL-12 in DCs.
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