FHIT基因是一个近年来发现的新的抑癌基因。
FHIT gene was a new be identified as tumour suppressor gene recently.
作者就目前在脑胶质瘤中研究较多的抑癌基因的进展作了综述。
The advances in the study of tumor suppressor genes in gliomas were reviewed.
FHIT是一种重要的抑癌基因，在多种肿瘤中被发现表达缺失。
FHIT is an important tumor suppressor gene, in a variety of tumors expression was found missing.
同样，这个重要的抑癌基因可能在流产中产生了重要的作用，它增加了流产发生的可能性。
They also raise the possibility that this important tumor-suppressor gene might play a role in miscarriages.
本项基因治疗策略以直接调控细胞周期的抑癌基因为靶向治疗基因，为肺癌基因治疗提供了可靠的理论依据。
The strategy targeted to the tumor suppressor gene that regulates the cell cycle directly, obtained satisfactory results, and provided a reliable theory for lung cancer gene therapy.
越来越多的研究发现FHIT基因在大量的原发性肿瘤及细胞株中存在异常，该基因被认为是一个候选的抑癌基因。
Abnormalities in the FHIT gene its expression have been identified in a variety of human cancer cell lines and tumors.
程序性细胞死亡因子4 (PDCD4)基因是首先在细胞凋亡中因一种表达特异的蛋白质而鉴别出来的一种新的抑癌基因。
Programmed cell death factor 4 (PDCD4) gene is a new anti-oncogene, which is firstly identified as a specific protein expressed in cell apoptosis.
近年来的研究发现，许多癌基因和抑癌基因相关产物为细胞生长、增殖、分化等信号转导途径的成员。
It is known that many related products of oncogenes and anti - oncogenes take part in the signal transduction of grow, proliferation and differentiation of cells.
由于该机制可影响特定抑癌基因的活性，因而与肿瘤形成密切相关。
This mechanism is particularly relevant in cancer since it can interfere with the activity of specific "suppressor" genes.
人抑癌基因，其编码的蛋白，含有其的表达载体和由该载体转化的细胞。
Human cancer suppressor gene, protein encoded therein, expression vector containing the same, and cell transformed by the vector.
目的探讨抑癌基因pten蛋白在大肠癌的表达及临床意义。
Objective To explore the expression and clinical significance of PTEN gene in large intestine carcinoma.
因此，探讨不同类型肿瘤相关癌基因和抑癌基因是认识肿瘤发生分子机理、开展基因诊断和基因治疗的基本前提。
Therefore, the detection of oncogenes and TSGs in different tumors is the basic prerequisite to understand the mechanism of tumorigenesis and to conduct gene diagnosis and gene therapy.
肿瘤形成与控制细胞生长和分化的多种基因特别是癌基因、抑癌基因的遗传改变有关。
There are multiple genes especially oncogenes and tumor suppressor genes involved in 'the genetic alterations which regulating the growth and differentiation of cells.
虽然有事实证明一些微小rna能够起癌基因或者抑癌基因，但是其在肿瘤的侵袭和转移中的作用尚未有研究。
Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored.
我们证明Chd5在活体中作为抑癌基因发挥作用而且在人类恶性肿瘤与CHD5的缺失有关。
We demonstrate that Chd5 functions as a tumor suppressor in vivo and implicate deletion of CHD5 in human cancer.
肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
胃癌的发生与多基因异常表达密切相关，其中抑癌基因甲基化是胃癌发生、展的重要机制之一。
The genesis of gastric cancer resulted from abnormal expression of many genes, and methylation of the tumor suppressor genes is one of the major mechanisms of gastric carcinogenesis.
其中涉及多种基因异常，包括易感基因、癌基因、抑癌基因等，对于乳腺癌的诊断、治疗及预后判断均具有提示作用。
Quite a few kinds of genes such as susceptibility gene, oncogene and tumor suppressor genes have been found with implications for diagnosis, therapy and prognosis.
热休克蛋白可能有助于细胞周期调控通过与原癌基因的产品或抑癌基因的产品。
Heat Shock Proteins may contribute to cell cycle regulation by interacting with proto-oncogene products or tumor suppressor gene products.
越来越多的证据表明，肿瘤的发生是多因素作用的结果，与癌基因的激活与抑癌基因的失活有关。
More and more evidence indicated that the formation of tumor is due to multi factors with oncogene activation and anti oncogene inactivation.
目的：从基因水平了解正常胃和胃癌组织原癌基因和抑癌基因表达的分子机制。
Objective: To study the expressions of pro-onc and tumor suppressor genes in gastric cancer by cDNA expression array.
D5S471和D5S592附近可能存在食管癌的候选抑癌基因。
There probably existed candidate tumor suppressor gene (s) around D5S592 and D5S471.
从石蜡包埋组织中提取DNA，是进一步研究抑癌基因的基础。
It is the foundation to further research anti-oncogene to extract DNA from paraffin embed constitution.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
癌基因和抑癌基因的发现，细胞信号传导通路的阐明，极大地丰富了人们对细胞癌变机制的认识。
The discovery of oncogenes and tumor suppressor genes, and the research of signal transduction pathway yield profound insights into the mechanisms of carcinogenesis.
目的研究抑癌基因pten对人膀胱癌细胞株biu- 87失巢凋亡的影响并探讨其可能的机制。
Objective To investigate the effect and mechanisms of tumor suppressor gene PTEN on the induction of anoikis of human bladder transitional carcinoma cells BIU-87.
而某些癌基因和抑癌基因对HIF-1表达及活性的影响最终决定着肿瘤的预后。
The influencing of some oncogene and anti-oncogene to the expression and activity of HIF-1 determines neoplastic prognosis ultimately.
而某些癌基因和抑癌基因对HIF-1表达及活性的影响最终决定着肿瘤的预后。
The influencing of some oncogene and anti-oncogene to the expression and activity of HIF-1 determines neoplastic prognosis ultimately.
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