他现在有很大的突破，希望类似的基因沉默过程。
He now has great hopes for similar breakthroughs with the process of gene silencing.
成熟microRNA与目标mRNA结合，形成了RNA诱导的基因沉默复合体。
The mature miRNA is incorporated into an RNA-induced silencing complex that binds to a target messenger RNA (mRNA).
其作用水平主要有三种：位置效应、转录水平的基因沉默和转录后水平的基因沉默。
The positions where transgene silencing occurs mainly are inserting position? transcriptional gene silencing and posttranscriptional gene silencing.
结果RNA干扰这一自然存在的、进化保守的抗病毒感染机制，导致序列特异的基因沉默。
Results RNA interference is one natural and conservative virus-inhibiting mechanism and can silence special gene sequence.
DNA甲基可以改变生物的形态，但是最近甲基化在真核生物中的基因沉默作用成为了科研的热点领域。
DNA methylation has a number of epigenetic functions, but the scientific interest has recently focused on the gene silencing effect methylation can have in eucaryotic cells.
目的近年来，双链rna介导的基因沉默(RNA干扰)已在许多动植物中发现，并成为研究基因功能的强有力的工具。
Objective Recently, a naturally occurring gene silencing mechanism triggered by double-stranded RNA (dsRNA), RNA interference (RNAi), has been described in a number of species including Drosophila.
他们认为，如果这些沉默的基因以某种方式被重新激活，长期丢失的性状可能会重新出现。
If these silent genes are somehow switched back on, they argued, long-lost traits could reappear.
但是，如果沉默基因在600万到1000万年内退化，那么失去已久的性状如何在更长的时间内被重新激活呢？
But if silent genes degrade within 6 to 10 million years, how can long-lost traits be reactivated over longer timescales?
不同的基因是如何以适当的组合方式来开始(表达)或停止(沉默)自己的工作，从而制造心脏、骨骼以及脑部细胞呢？
How do different genes get turned on (" expressed ") or off (" silenced ") in just the right combinations to produce heart cells, bone cells and brain cells?
基因组的某些区域天生就以高速率转录成蛋白质，而其它区域则基本上保持沉默。
Some regions of the genome are naturally transcribed into proteins at a high rate, whereas other regions are essentially silent.
人类携带有许多可以阻止肿瘤生长的基因，但是，如果表观基因组受到了破坏，就会有效地使这些基因沉默，使人体更有可能罹患癌症。
Humans carry a number of genes that stop tumours from growing, but disruption to the epigenome can effectively silence these genes, making it more likely a person will develop cancer.
但是一个不同寻常的利益冲突意味着制药公司基因泰克对此格外地沉默。
But an unusual conflict of interest means that Genentech, the drug company that produces Lucentis, is conspicuously silent.
2004年麦吉尔大学的大鼠试验发现母鼠的某些特定行为使幼鼠大脑海马区的某些基因沉默，小鼠处理应激激素的能力因而下降。
A 2004 McGill University study of lab rats found that certain maternal behaviors can silence a gene in the hippocampi of their pups, leaving them less able to handle stress hormones.
“唯一表达合胞体蛋白的地方是胎盘，”海德曼博士说，为了弄清楚它的功能，他及其同事在老鼠上沉默了该基因。
"The only place it's expressed is in the placenta," Dr. Heidmann said. To understand its function, he and his colleagues disabled the gene in mice.
这个基因在酵母中称为SIR - 1，意思是沉默信息调节子，在人类和白鼠中，与其相应的基因称为SIRT - 1。
The gene is known as Sir-2 in yeast, Sir Standing for silent information regulator, and its equivalent in mice and humans is called SIRT-1.
瑞士的研究组利用RNA干扰技术使相关基因沉默来研究这条通路。
The Swiss team studied the pathway by using RNA interference to silence genes involved.
一组称为多梳抑制复合物1（PRC1）蛋白质沉默基因必须先结合到特定的组蛋白上的甲基化位点。
A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and.
在某种情况下，该方法将会用来沉默一些能引发诸如心衰或者癌症的不好的基因。
In some cases, the method will be used to switch off rogue genes that promote conditions such as heart failure or cancer.
但是该研究显示，至少有一些临床测试的药物实际工作原理不是通过基因沉默，而是激活免疫系统。
But the study suggests that at least some drugs now being tested in clinical trials actually work not by silencing genes but by activating the immune system.
报告指出，得到的结果表明基因沉默可能是“一个有效的和更具体的治疗肝纤维化的方法”。
The results suggest that gene silencing may be "an efficient and more specific approach for therapy of liver fibrosis, " the report states.
筛选工作通过沉默每个基因来评估该基因在药物作用中的功能。
The screen works by silencing each gene in turn to assess its effect on how well the drug works.
基因沉默系统也可以用来治疗病毒疾病，总的来说生物技术能够帮助我们生产更多的茁壮的庄稼。
The gene silencing system can also be used to combat virus diseases, and biotechnology in general can help us produce more robust crops.
这些分子可对环境的影响作出应答，根据需要令一些基因沉默，并激活其他基因。
These molecules can respond to environmental influences by silencing some genes and activating others as needed.
研究人员已经发明了精敏的新技术，来模拟化学药品，在紧密结合的沉默基因表达的DNA -蛋白复合体上做标记。
Researchers have devised clever new techniques to mimic the chemical marks on tightly wound DNA-protein complexes that silence gene expression.
在任一点阻断这条通路，或者沉默与炎症小体形成相关的基因或者编码半胱天冬酶- 1的基因，都能导致细胞死亡数目增加。
Interrupting the pathway at any point, either by silencing the genes responsible for the inflammasome formation or the gene for caspase-1, resulted in increased cell death.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
这些药物设计为可以激活rna干扰，从而沉默具有与药物序列相符合的编码的基因。
The drugs are designed to activate RNA interference to silence a gene with a sequence of letters of the genetic code corresponding to the sequence in the drug.
这些药物设计为可以激活rna干扰，从而沉默具有与药物序列相符合的编码的基因。
The drugs are designed to activate RNA interference to silence a gene with a sequence of letters of the genetic code corresponding to the sequence in the drug.
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