目的检测针对端粒酶rna的反义寡核苷酸对鼻咽癌hne - 1细胞株生长的影响。
Objective To investigate the effects of AS-ODN targeting against telomerase RNA on the growth of HNE-1 cell line.
结果：作用靶点不同的反义寡核苷酸对KB - A - 1细胞生长的抑制能力不同。
Results: the abilities of antisense oligonucleotides to inhibit the cell growth of KB-A-1 mainly depended upon their targeted sequences selected.
目的：探讨端粒酶逆转录酶(TERT)的反义寡核苷酸(A SODN)对甲状腺癌(TC)细胞凋亡的影响。
AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.
目的：探讨反义寡核苷酸对胆囊癌细胞端粒酶活性的影响及对胆囊癌细胞生长增殖的作用。
Objective: To study the antisense oligonucleotide mediated inhibition on telomerase activity and cell proliferation of GBC-SD cell.
目的评价生存素反义寡核苷酸在荷肝癌小鼠中的治疗作用。
Objective To evaluate the therapeutic effect of antisense oligonucleotide targeting Survivin in the treatment of tumor-bearing nude mice.
目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。
Objective: To investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.
目的探讨IL12反义寡核苷酸对狼疮肾炎(LN)患者单个核细胞(PBMC)分泌免疫球蛋白的影响。
Objective To investigate the effect of IL 12 antisense oligonucleotides on immunoglobulin secretion by PBMC from patients with active lupus nephritis (LN).
目的观察vegf反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides.
结果PCNA反义寡核苷酸可明显抑制BT325细胞的生长；
Results PCNA antisense oligodeoxynucleotides could significantly inhibit the growth of BT325 cells line.
目的探讨辐射促转染的胰岛素样生长因子1受体(IGF 1r)反义寡核苷酸(ason)对肿瘤组织的杀伤效果。
Objective to investigate the killing effect of insulin-like growth factor-1 receptor (IGF-1R) antisense oligodeoxynucleotides (ASON) in combination with ionizing radiation on tumor.
目的探讨超声介导脂质体微气泡转染反义寡核苷酸ha- 2741的有效性。
Objective To explore the efficiency of transfection of antisense oligonucleotides HA-2741 by ultrasound mediated liposome microbubbles.
目的：筛选出高效特异而无毒的抗hbv反义寡核苷酸片段。
Objective: to screen the high performance, specific and nontoxic anti HBV antisense oligonucleotide fragment.
目的观察增殖细胞核抗原（PCNA）基因反义脱氧寡核苷酸对人多形性胶质母细胞瘤细胞增殖的影响。
Objective To observe the effect of proliferating cells nuclear antigen (PCNA) antisense oligodeoxynucleotides on the proliferation of human multiform glioblastoma cells.
采用DAPI染色技术观察hpk1反义寡核苷酸对OGD诱导的海马神经元凋亡的作用。
DAPI staining was used to investigate the role of HPK1 antisense oligodeoxynucleotides in hippocampus neuron death induced by OGD.
目的研究角质形成细胞生长因子(KGF)及其受体(KGFR)反义寡核苷酸对KGF介导的细胞周期和凋亡变化的抑制作用。
Objective to investigate the effects of keratinocyte growth factor (KGF) and KGF receptor (KGFR) antisense oligonucleotide (ASODN) on cell cycle and apoptosis of HaCat cells.
结果VEGF反义寡核苷酸对膀胱癌细胞的VEGF表达有明显的抑制作用。
Results VEGF antisense oligonucleotides obviously inhibited VEGF expression in human bladder carcinoma cells and proliferation of endothelial cells.
成功的反义显像要求反义寡核苷酸易被细胞摄取、耐核酸酶、杂交稳定、标记简单。
The requirements for ideal antisense imaging include easy intakeing by cells, convenient labelling, stable hybridization and the tolerance against nuclease.
方法将SPA-PLL交联物、CD44抗体和反义寡核苷酸以适宜的质量比混合即可组装成抗体靶向寡核苷酸复合物；
Methods The antibody-targeted complex could be prepared by mixing SPA-PLL conjugate, oligodeoxy nucleotide and anti-CD44 antibody based on their optimal mass ratio.
目的：观察eb病毒BHRF 1反义寡核苷酸片段对鼻咽癌SUNE1细胞株增殖的影响。
Objective: To investigate the effects of EBV BHRF1 antisense oligodeoxynucleotide (aso) on the proliferation of poorly differentiated nasopharyngeal carcinoma (SUNE1) cell lines.
MTT法检测加入反义寡核苷酸后对转染的包装细胞生长的影响。
MTT was used to detect the cell growth of the packaging cells.
基因治疗是将DNA转染进入目的细胞，修复遗传错误或产生治疗因子。反义寡核苷酸的应用是基因治疗的主要手段之一。
The aim of gene therapy is to transfect DNA into target cells, in which utilizing antisense oligonucleotides is a main method.
与单独使用反义寡核苷酸相比较，萘二酰亚胺对寡核苷酸的共价修饰显著地提高了反义寡核苷酸对KB-A - 1细胞生长的抑制。
Compared with the unmodified one, the inhibition of antisense oligonucleotides to the growth of KB - a - 1 cell was increased by conjugating with naphthyl imide.
目的探讨IGF - IR反义寡核苷酸对食管癌ec9706细胞增殖、分化的影响。
Objective To investigate the effects of antisense oligodeoxynucleotides (ASODNs) of IGF-IR on the proliferation and differentiation of EC9706 cell line.
【摘要】目的探讨增殖细胞核抗原(pcna)反义寡核苷酸对大鼠胶质瘤生长的抑制作用。
Abstract Objective to study the inhibitory effect of PCNA antisense oligonucleotides on the growth of rat glioma.
研究人员将取自12日龄大鼠的下颌骨髁突在含有IGF - I反义寡核苷酸(AS -ODN)的培养基中培养1、3和5天。
Mandibular condyles dissected from 12-day-old rats were cultured for 1, 3, and 5 days in medium containing antisense oligodeoxynucleotide (AS-ODN) for IGF-I.
目的：观察酰基辅酶a：胆固醇酰基转移酶1 (ACAT1)反义寡核苷酸对泡沫细胞(FC)形成的影响。
AIM: To study the effect of acyl coenzyme a: cholesteryl acyltransferase 1 (ACAT1) antisense oligonucleotides on the formation of foam cells (FC).
本研究目的旨在观察脂质体介导的VEGF - C反义寡核苷酸对肺癌裸鼠皮下种植瘤模型微淋巴管生成的影响。
The aim of this article is to investigate the effects on lymphangiogenesis of orthotopic implantation of lung cancer in nude mice with antisense oligonucleotides of VEGF-C.
更多的支持治疗HCV的新药品是Albuferon、日达仙，反义的磷酸寡核苷酸已经用来治疗丙型肝炎。
Some more modern new drugs that provide some support in treating HCV are Albuferon, Zadaxin,. Antisense phosphorothioate oligos have been targeted to hepatitis C.
经修饰寡核苷酸克服了与当前反义药物有关的许多问题。
The modified oligonucleotides overcome many problems associated with current antisense drugs.
经修饰寡核苷酸克服了与当前反义药物有关的许多问题。
The modified oligonucleotides overcome many problems associated with current antisense drugs.
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