目的：鉴定自制的抗CD3-抗胶质瘤双特异性抗体（双抗）的双向结合能力，测定其免疫活性及其对T淋巴细胞的作用。
Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb) , and to study its effect on T lymphocytes cells.
结论建立的双抗体夹心elisa检测MP抗原具有快速、简便、灵敏度高、特异性强等优点。
Conclusions Antibody-sandwich ELISA for detection of mp antigen is simple, rapid, sensitive and specific.
还提供了包含本发明抗体的免疫偶联物、双特异性分子和药物组合物。
Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided.
还提供免疫缀合物、双特异性分子以及包含本发明抗体和任选地一种或多种其它治疗剂的药物组合物。
Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic.
本发明描述了三官能双特异性抗体用于制备用来预防和治疗肿瘤疾病的药物组合物的应用。
The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases.
采用免疫双扩法鉴定单克隆抗体类型，ELISA法、免疫双扩法鉴定单克隆抗体的特异性。
Double immunodiffusion assay was used to identify the type and subclass of monoclonal antibody. ELISA and double immunodiffusion assay were used to determine the specificity.
本发明涉及一种制备异多聚体多肽如双特异性抗体、双特异性免疫粘附素和抗体—免疫粘附素嵌合体的方法。
The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras.
本发明涉及一种制备异多聚体多肽如双特异性抗体、双特异性免疫粘附素和抗体—免疫粘附素嵌合体的方法。
The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras.
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